Abstract
• An in vitro broad-spectrum antifungal activity of Brevibacillus brevis HK544. • A promising disease control efficacy for tomato gray mold and tomato late blight. • B. brevis HK544 CF had a synergistic effect with benomyl in vitro and in vivo. Chemical fungicides have been widely used to control plant diseases caused by fungal pathogens. Still, the overuse of these fungicides has led to concerns about the hazards to humans, animals, and the environment and an increase in fungicide resistance. Interest in biocontrol agents with strong antimicrobial activity has significantly increased to counteract the escalating risks of chemical fungicides. Our previous study found that a soil-born microbe, Brevibacillus brevis HK544, exhibited a promising antifungal activity against a plant pathogen, Fusarium graminearum , with edeine B 1 identified as the active compound. Herein, we extended our study to investigate the in vitro and in vivo antifungal spectrum of B. brevis HK544, including edeine B 1 , against various plant pathogenic fungi and evaluated the possibility that B. brevis HK544 could be used in combination with chemical fungicides to enhance the disease control efficacy. With an in vitro broad-spectrum antifungal activity, the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases. Based on the in vitro antifungal activity against Botrytis cinerea , when edeine B 1 was combined with various chemical fungicides, the highest average synergy score among the tested combinations was observed in the edeine B 1 and benomyl combination. The co-application of the B. brevis HK544 culture filtrate and benomyl improved the disease control efficacy against gray mold disease, supporting the in vitro result. Taken together, our results show that B. brevis HK544 has potential as a biological control agent for controlling plant pathogenic fungi and also that B. brevis HK544 could be combined with chemical fungicides to enhance the efficacy of antifungal agents.
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Claims 9
Claim · model-written summary
B. brevis HK544 culture filtrate showed broad antifungal activity in vitro.
- Taxon
- tomato
Solanum lycopersicume1 - Interactor
- Brevibacillus brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- in vitro broad-spectrum antifungal activity of Brevibacillus brevis HK544e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“An in vitro broad-spectrum antifungal activity of Brevibacillus brevis HK544.”
e1“promising disease control efficacy for tomato gray mold and tomato late blight”
Claim · model-written summary
B. brevis HK544 culture filtrate controlled tomato gray mold.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- B. brevis HK544 culture filtratee0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- tomato gray molde0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases.”
Claim · model-written summary
B. brevis HK544 culture broth controlled tomato gray mold.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- culture brothe0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- tomato gray molde0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases.”
Claim · model-written summary
Edeine B 1 controlled tomato gray mold.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- edeine B 1e0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- tomato gray molde0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases.”
Claim · model-written summary
B. brevis HK544 culture filtrate controlled tomato late blight.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- B. brevis HK544 culture filtratee0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- tomato late blighte0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases.”
Claim · model-written summary
B. brevis HK544 culture broth controlled tomato late blight.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- culture brothe0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- tomato late blighte0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases.”
Claim · model-written summary
Edeine B 1 controlled tomato late blight.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- edeine B 1e0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- tomato late blighte0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the B. brevis HK544 culture filtrate, culture broth, and metabolite edeine B 1 exhibited a promising disease control efficacy against tomato gray mold and tomato late blight among the tested fungal diseases.”
Claim · model-written summary
Edeine B 1 with benomyl had the highest average synergy score among tested fungicide combinations against B. cinerea in vitro.
- Taxon
- tomatoSolanum lycopersicume1
- Treatment
- edeine B 1 and benomyl combinatione0
- Interactor
- Botrytis cinerea
Botrytis cinereae0pathogen - Outcome
- average synergy scoree0
- Direction
- higheste0
- Comparator
- tested combinationse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Based on the in vitro antifungal activity against Botrytis cinerea , when edeine B 1 was combined with various chemical fungicides, the highest average synergy score among the tested combinations was observed in the edeine B 1 and benomyl combination.”
e1“promising disease control efficacy for tomato gray mold and tomato late blight”
Claim · model-written summary
Co-application of B. brevis HK544 culture filtrate and benomyl improved gray mold disease control.
- Taxon
- tomatoSolanum lycopersicume1
- Treatment
- co-application of the B. brevis HK544 culture filtrate and benomyle0
- Interactor
- B. brevis HK544Brevibacillus brevise0biocontrol_agent
- Outcome
- disease control efficacy against gray mold diseasee0
- Direction
- improvede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The co-application of the B. brevis HK544 culture filtrate and benomyl improved the disease control efficacy against gray mold disease, supporting the in vitro result.”
e1“promising disease control efficacy for tomato gray mold and tomato late blight”
The same questions in other papers
benomyl · Botrytis cinerea · Solanum lycopersicum (tomato)Results agree
2 papers in the same direction as this paper
- positive
- positive
pathogen product · control · Solanum lycopersicum (tomato)Positive and negative results
2 papers in the same direction as this paper · 1 in the opposite direction
- negative
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pathogen product · disease · Solanum lycopersicum (tomato)Positive and negative results
25 papers in the same direction as this paper · 6 in the opposite direction
- negative
- negative
- negative
28 papers more in this group
See all 32 papers →pathogen product · organism · Solanum lycopersicum (tomato)Results agree
3 papers in the same direction as this paper
- positive
- positive
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.