Abstract
The standardized 80% ethanolic extract of the leaves of Ocimum basilicum var. thyrsiflorum (L.) Benth., Lamiaceae, growing in KSA, exhibited a significant antioxidant activity compared to the ethyl acetate and butanol extracts, which was correlated to its higher phenolic and flavonoid contents. Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3″-O-acetylvitexin. Compound 3″-O-acetylvitexin, a C-glycosylated derivative of apigenin, was isolated for the first time from genus Ocimum. The 80% ethanolic extract and 3″-O-acetylvitexin showed significant cytotoxic activities against the HCT116 human colon cancer cell line [IC50 values 22.3 ± 1.1 and 16.8 ± 2.0 μg/ml (35.4 μM), respectively].
Abstract from the paper’s OpenAlex record; open copy licensed cc-by-nc-nd. Read at the source ↗
The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.
Claims 9
Claim · model-written summary
The standardized ethanolic basil leaf extract had greater antioxidant activity than ethyl acetate and butanol extracts.
- Taxon
- Ocimum basilicum var. thyrsiflorum
Ocimum basilicum var. thyrsiflorume0 - Treatment
- 80% ethanolic extracte0
- Outcome
- antioxidant activitye0
- Direction
- increaseinferrede0
- Comparator
- ethyl acetate and butanol extractse0
- Setting
- KSAe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The standardized 80% ethanolic extract of the leaves of Ocimum basilicum var. thyrsiflorum (L.) Benth., Lamiaceae, growing in KSA, exhibited a significant antioxidant activity compared to the ethyl acetate and butanol extracts”
Claim · model-written summary
The greater antioxidant activity of the ethanolic extract correlated with higher phenolic and flavonoid contents.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Outcome
- phenolic and flavonoid contentse0
- Direction
- highere0
- Qualifier
- correlatede0
Not reportedCompoundTreatment
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“which was correlated to its higher phenolic and flavonoid contents.”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
Claim · model-written summary
Chromatography isolated cinnamic acid, gallic acid, and methylgallate from the ethanolic extract.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Outcome
- cinnamic acid, gallic acid, methylgallatee0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3″-O-acetylvitexin.”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
Claim · model-written summary
Chromatography isolated ellagic acid, methyl ellagic acid, and apigenin.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Outcome
- ellagic acid, methyl ellagic acid, apigenine0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3″-O-acetylvitexin.”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
Claim · model-written summary
Chromatography isolated luteolin, vitexin, and isovitexin.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Outcome
- luteolin, vitexin, isovitexine0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3″-O-acetylvitexin.”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
Claim · model-written summary
Chromatography isolated 3″-O-acetylvitexin.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Outcome
- 3″-O-acetylvitexine0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3″-O-acetylvitexin.”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
Claim · model-written summary
3″-O-acetylvitexin was isolated from genus Ocimum for the first time.
OcimumNot reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Compound 3″-O-acetylvitexin, a C-glycosylated derivative of apigenin, was isolated for the first time from genus Ocimum.”
Claim · model-written summary
The ethanolic extract showed significant cytotoxicity against HCT116 cells with IC50 22.3 ± 1.1 μg/ml.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Treatment
- 80% ethanolic extracte0
- Outcome
- cytotoxic activitiese0
- Value
- 22.3 ± 1.1e0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The 80% ethanolic extract and 3″-O-acetylvitexin showed significant cytotoxic activities against the HCT116 human colon cancer cell line [IC50 values 22.3 ± 1.1 and 16.8 ± 2.0 μg/ml (35.4 μM), respectively].”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
Claim · model-written summary
3″-O-acetylvitexin showed significant cytotoxicity against HCT116 cells with IC50 16.8 ± 2.0 μg/ml.
- Taxon
- Ocimum basilicum var. thyrsiflorumOcimum basilicum var. thyrsiflorumt0
- Treatment
- 3″-O-acetylvitexine0
- Outcome
- cytotoxic activitiese0
- Value
- 16.8 ± 2.0 μg/ml (35.4 μM)e0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The 80% ethanolic extract and 3″-O-acetylvitexin showed significant cytotoxic activities against the HCT116 human colon cancer cell line [IC50 values 22.3 ± 1.1 and 16.8 ± 2.0 μg/ml (35.4 μM), respectively].”
t0“A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum”
The same questions in other papers
botanical · quality: phytochemicals · Ocimum basilicum (basil)Results agree
3 papers in the same direction as this paper
- positive
- positive
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.