Abstract
In plants, systemic acquired resistance (SAR) is established as a result of NPR1-regulated expression of pathogenesis-related (PR) genes. Using gene expression profiling in Arabidopsis, we found that in addition to controlling the expression of PR genes, NPR1 also directly controls the expression of the protein secretory pathway genes. Up-regulation of these genes is essential for SAR, because mutations in some of them diminished the secretion of PR proteins (for example, PR1), resulting in reduced resistance. We provide evidence that NPR1 coordinately regulates these secretion-related genes through a previously undescribed cis-element. Activation of this cis-element is controlled by a transcription factor that is translocated into the nucleus upon SAR induction.
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Claims 5
Claim · model-written summary
NPR1 directly controls expression of protein secretory pathway genes in Arabidopsis.
- Taxon
- Arabidopsis
Arabidopsise0 - Gene
- NPR1e0
- Outcome
- expression of the protein secretory pathway genese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Using gene expression profiling in Arabidopsis, we found that in addition to controlling the expression of PR genes, NPR1 also directly controls the expression of the protein secretory pathway genes”
Claim · model-written summary
Mutations in secretory pathway genes diminished PR protein secretion and resistance.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- mutations in some of theme0
- Gene
- PR1e0
- Outcome
- secretion of PR proteinse0
- Direction
- diminishede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mutations in some of them diminished the secretion of PR proteins (for example, PR1), resulting in reduced resistance”
e1“Arabidopsis”
Claim · model-written summary
Mutations in secretory pathway genes reduced systemic acquired resistance.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- mutations in some of theme0
- Outcome
- resistancee0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mutations in some of them diminished the secretion of PR proteins (for example, PR1), resulting in reduced resistance”
e1“Arabidopsis”
Claim · model-written summary
NPR1 coordinately regulates secretion-related genes through a previously undescribed cis-element.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- NPR1e0
- Outcome
- regulates these secretion-related genese0
- Qualifier
- through a previously undescribed cis-elemente0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“NPR1 coordinately regulates these secretion-related genes through a previously undescribed cis-element”
e1“Arabidopsis”
Claim · model-written summary
A transcription factor translocated to the nucleus on SAR induction controls activation of the cis-element.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- a transcription factore0
- Outcome
- Activation of this cis-elemente0
- Qualifier
- translocated into the nucleus upon SAR inductione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Activation of this cis-element is controlled by a transcription factor that is translocated into the nucleus upon SAR induction”
e1“Arabidopsis”
The same questions in other papers
loss of function · disease · ArabidopsisPositive and negative results
100 papers in the same direction as this paper · 46 in the opposite direction
- negative
- no effect
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