Abstract
The enhanced disease resistance 1 (edr1) mutation of Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum. Resistance mediated by the edr1 mutation is correlated with induction of several defense responses, including host cell death. Double mutant analysis revealed that all edr1-associated phenotypes are suppressed by mutations that block salicylic acid (SA) perception (nim1) or reduce SA production (pad4 and eds1). The NahG transgene, which lowers endogenous SA levels, also suppressed edr1. In contrast, the ein2 mutation did not suppress edr1-mediated resistance and associated phenotypes, indicating that ethylene and jasmonic acid-induced responses are not required for edr1 resistance. The EDR1 gene was isolated by positional cloning and was found to encode a putative MAP kinase kinase kinase similar to CTR1, a negative regulator of ethylene responses in Arabidopsis. Taken together, these data suggest that EDR1 functions at the top of a MAP kinase cascade that negatively regulates SA-inducible defense responses. Putative orthologs of EDR1 are present in monocots such as rice and barley, indicating that EDR1 may regulate defense responses in a wide range of crop species.
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Claims 12
Claim · model-written summary
The Arabidopsis edr1 mutation confers resistance to Erysiphe cichoracearum powdery mildew.
- Taxon
- Arabidopsis
Arabidopsise0 - Interactor
- Erysiphe cichoracearum
Golovinomyces cichoracearume0pathogen - Gene
- edr1e0
- Outcome
- resistance to powdery mildew diseasee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The enhanced disease resistance 1 (edr1) mutation of Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
Resistance from edr1 correlated with induction of several defense responses, including host cell death.
- Taxon
- ArabidopsisArabidopsise1
- Interactor
- Erysiphe cichoracearumGolovinomyces cichoracearume1pathogen
- Gene
- edr1e0
- Outcome
- induction of several defense responses, including host cell deathe0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Resistance mediated by the edr1 mutation is correlated with induction of several defense responses, including host cell death.”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
nim1 mutations suppressed all edr1-associated phenotypes.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- mutations that block salicylic acid (SA) perception (nim1)e0
- Interactor
- Erysiphe cichoracearumGolovinomyces cichoracearume1pathogen
- Gene
- nim1e0
- Outcome
- edr1-associated phenotypese0
- Direction
- suppressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“all edr1-associated phenotypes are suppressed by mutations that block salicylic acid (SA) perception (nim1)”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
pad4 mutations suppressed all edr1-associated phenotypes.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- pad4e0
- Interactor
- Erysiphe cichoracearumGolovinomyces cichoracearume1pathogen
- Gene
- pad4e0
- Outcome
- edr1-associated phenotypese0
- Direction
- suppressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“all edr1-associated phenotypes are suppressed by mutations that block salicylic acid (SA) perception (nim1) or reduce SA production (pad4 and eds1)”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
eds1 mutations suppressed all edr1-associated phenotypes.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- eds1e0
- Interactor
- Erysiphe cichoracearumGolovinomyces cichoracearume1pathogen
- Gene
- eds1e0
- Outcome
- edr1-associated phenotypese0
- Direction
- suppressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“all edr1-associated phenotypes are suppressed by mutations that block salicylic acid (SA) perception (nim1) or reduce SA production (pad4 and eds1)”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
The NahG transgene suppressed edr1.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- NahG transgenee0
- Interactor
- Erysiphe cichoracearumGolovinomyces cichoracearume1pathogen
- Gene
- NahGe0
- Outcome
- edr1e0
- Direction
- suppressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The NahG transgene, which lowers endogenous SA levels, also suppressed edr1.”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
The ein2 mutation did not suppress edr1 resistance or associated phenotypes.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- ein2 mutatione0
- Interactor
- Erysiphe cichoracearumGolovinomyces cichoracearume1pathogen
- Gene
- ein2e0
- Outcome
- edr1-mediated resistance and associated phenotypese0
- Direction
- did not suppresse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the ein2 mutation did not suppress edr1-mediated resistance and associated phenotypes”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
EDR1 encodes a putative MAP kinase kinase kinase similar to CTR1.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- EDR1e0
- Outcome
- putative MAP kinase kinase kinase similar to CTR1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The EDR1 gene was isolated by positional cloning and was found to encode a putative MAP kinase kinase kinase similar to CTR1, a negative regulator of ethylene responses in Arabidopsis.”
Claim · model-written summary
EDR1 was isolated by positional cloning.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- EDR1e0
- Outcome
- EDR1 genee0
Not reportedComparatorValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The EDR1 gene was isolated by positional cloning”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
EDR1 is suggested to negatively regulate SA-inducible defense responses at the top of a MAP kinase cascade.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- EDR1e0
- Outcome
- SA-inducible defense responsese0
- Direction
- negatively regulatese0
- Qualifier
- top of a MAP kinase cascadee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“these data suggest that EDR1 functions at the top of a MAP kinase cascade that negatively regulates SA-inducible defense responses.”
e1“Arabidopsis confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum.”
Claim · model-written summary
Putative EDR1 orthologs were found in rice.
- Taxon
- rice
Oryza sativae0 - Gene
- EDR1e0
- Outcome
- Putative orthologs of EDR1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Putative orthologs of EDR1 are present in monocots such as rice and barley”
Claim · model-written summary
Putative EDR1 orthologs were found in barley.
- Taxon
- barley
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Hordeum vulgaree0 - Gene
- EDR1e0
- Outcome
- Putative orthologs of EDR1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“Putative orthologs of EDR1 are present in monocots such as rice and barley”
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See all 7 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.