Abstract
Medicinal plants play important roles in traditional medicine, and numerous compounds among them have been recognized for their antimicrobial activity. However, little is known about the potential of Vietnamese medicinal plants for antifungal activity. In this study, we examined the antagonistic activity of twelve medicinal plant species collected in Northern Vietnam against Penicillium digitatum, Aspergillus flavus, Aspergillus fumigatus, and Candida albicans. The results showed that the antifungal activities of the crude extracts from Mahonia bealei, Ficus semicordata, and Gnetum montanum were clearly detected with the citrus postharvest pathogen P. digitatum. These extracts could fully inhibit the growth of P. digitatum on the agar medium, and on the infected citrus fruits at concentrations of 300–1000 µg/mL. Meanwhile, the other tested fungi were less sensitive to the antagonistic activity of the plant extracts. In particular, we found that the ethanolic extract of M. bealei displayed a broad-spectrum antifungal activity against all four pathogenic fungi. Analysis of this crude extract by enrichment coupled with high-performance liquid chromatography revealed that berberine and palmatine are major metabolites. Additional inspections indicated berberine as the key compound responsible for the antifungal activity of the M. bealei ethanolic extract. Our study provides a better understanding of the potential of Vietnamese medicinal plant resources for combating fungal pathogens. This work also highlights that the citrus pathogen P. digitatum can be employed as a model fungus for screening the antifungal activity of botanicals.
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Claims 8
Claim · model-written summary
Crude extracts from three medicinal plants showed antifungal activity against P. digitatum.
- Interactor
- P. digitatum
Penicillium digitatume0pathogen - Outcome
- antifungal activitiese0
CitrusOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“antifungal activities of the crude extracts from Mahonia bealei, Ficus semicordata, and Gnetum montanum were clearly detected with the citrus postharvest pathogen P. digitatum”
Claim · model-written summary
The extracts fully inhibited P. digitatum growth on agar medium.
- Taxon
- P. digitatumPenicillium digitatume0
- Outcome
- growth of P. digitatume0
- Direction
- fully inhibite0
- Setting
- agar mediume0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“These extracts could fully inhibit the growth of P. digitatum on the agar medium”
Claim · model-written summary
The extracts fully inhibited P. digitatum on infected citrus fruits at 300–1000 µg/mL.
- Treatment
- These extractse0
- Interactor
- P. digitatumPenicillium digitatume0pathogen
- Outcome
- growth of P. digitatume0
- Direction
- fully inhibite0
- Value
- 300–1000 µg/mLe0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“These extracts could fully inhibit the growth of P. digitatum on the agar medium, and on the infected citrus fruits at concentrations of 300–1000 µg/mL”
Claim · model-written summary
Other tested fungi were less sensitive to the plant extracts.
Verbatim
e0“the other tested fungi were less sensitive to the antagonistic activity of the plant extracts”
Claim · model-written summary
M. bealei ethanolic extract showed broad-spectrum antifungal activity against four pathogenic fungi.
Verbatim
e0“ethanolic extract of M. bealei displayed a broad-spectrum antifungal activity against all four pathogenic fungi”
Claim · model-written summary
Berberine and palmatine were major metabolites in M. bealei extract.
- Taxon
- M. bealei
_Berberis_bealei_habitus.jpg?width=60)
Berberis bealeie1 - Outcome
- berberine and palmatine are major metabolitese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Berberis_bealei_habitus.jpg?width=500)
Verbatim
e0“this crude extract by enrichment coupled with high-performance liquid chromatography revealed that berberine and palmatine are major metabolites”
e1“M. bealei ethanolic extract”
Claim · model-written summary
Berberine was identified as the key antifungal compound in M. bealei extract.
- Taxon
- M. bealeiBerberis bealeie0
- Compound
- berberinee0
- Outcome
- antifungal activitye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“berberine as the key compound responsible for the antifungal activity of the M. bealei ethanolic extract”
Claim · model-written summary
The authors propose P. digitatum as a model for screening botanical antifungal activity.
- Interactor
- P. digitatumPenicillium digitatume0pathogen
- Outcome
- screening the antifungal activity of botanicalse0
Not reportedComparatorValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the citrus pathogen P. digitatum can be employed as a model fungus for screening the antifungal activity of botanicals”
The same questions in other papers
botanical · Penicillium digitatum · CitrusPositive and negative results
10 papers in the same direction as this paper · 1 in the opposite direction
- no effect
- positive
- positive
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See all 12 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.