Abstract
Plants have evolved sophisticated regulatory networks to cope with dynamically changing light and temperature environments during day-night and seasonal cycles. However, the integration mechanisms of light and low temperature remain largely unclear. Here, we show that low red : far-red ratio (LR : FR) induces FAR-RED ELONGATED HYPOCOTYL3 (SlFHY3) transcription under cold stress in tomato (Solanum lycopersicum). Reverse genetic approaches revealed that knocking out SlFHY3 decreases myo-inositol accumulation and increases cold susceptibility, whereas overexpressing SlFHY3 induces myo-inositol accumulation and enhances cold tolerance in tomato plants. SlFHY3 physically interacts with ELONGATED HYPOCOTYL5 (SlHY5) to promote the transcriptional activity of SlHY5 on MYO-INOSITOL-1-PHOSPHATE SYNTHASE 3 (SlMIPS3) and induce myo-inositol accumulation in tomato plants under cold stress. Disruption of SlHY5 and SlMIPS3 largely suppresses the cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulation in tomato. Furthermore, silencing of SlMIPS3 drastically reduces myo-inositol accumulation and compromises LR : FR-induced cold tolerance in tomato. Together, our results reveal a crucial role of SlFHY3 in LR : FR-induced cold tolerance in tomato and unravel a novel regulatory mechanism whereby plants integrate dynamic environmental light signals and internal cues (inositol biosynthesis) to induce and control cold tolerance in tomato plants.
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Claims 13
Claim · model-written summary
Low red:far-red ratio induced SlFHY3 transcription under cold stress in tomato.
- Taxon
- tomato
Solanum lycopersicume0 - Treatment
- low red : far-red ratio (LR : FR)e0
- Gene
- SlFHY3e0
- Outcome
- transcriptione0
- Direction
- inducese0
- Qualifier
- under cold stresse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“low red : far-red ratio (LR : FR) induces FAR-RED ELONGATED HYPOCOTYL3 (SlFHY3) transcription under cold stress in tomato (Solanum lycopersicum).”
Claim · model-written summary
SlFHY3 knockout decreased myo-inositol accumulation.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- knocking out SlFHY3e0
- Gene
- SlFHY3e0
- Outcome
- myo-inositol accumulatione0
- Direction
- decreasese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“knocking out SlFHY3 decreases myo-inositol accumulation and increases cold susceptibility, whereas overexpressing SlFHY3 induces myo-inositol accumulation and enhances cold tolerance in tomato plants.”
Claim · model-written summary
SlFHY3 knockout increased cold susceptibility.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- knocking out SlFHY3e0
- Outcome
- cold susceptibilitye0
- Direction
- increasese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“knocking out SlFHY3 decreases myo-inositol accumulation and increases cold susceptibility, whereas overexpressing SlFHY3 induces myo-inositol accumulation and enhances cold tolerance in tomato plants.”
Claim · model-written summary
SlFHY3 overexpression induced myo-inositol accumulation.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- overexpressing SlFHY3e0
- Outcome
- myo-inositol accumulatione0
- Direction
- inducese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“overexpressing SlFHY3 induces myo-inositol accumulation and enhances cold tolerance in tomato plants.”
Claim · model-written summary
SlFHY3 overexpression enhanced cold tolerance.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- overexpressing SlFHY3e0
- Outcome
- cold tolerancee0
- Direction
- enhancese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“overexpressing SlFHY3 induces myo-inositol accumulation and enhances cold tolerance in tomato plants.”
Claim · model-written summary
SlFHY3 physically interacted with SlHY5.
- Taxon
- tomatoSolanum lycopersicume0
- Gene
- SlFHY3e0
- Outcome
- physically interacts with ELONGATED HYPOCOTYL5 (SlHY5)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SlFHY3 physically interacts with ELONGATED HYPOCOTYL5 (SlHY5) to promote the transcriptional activity of SlHY5 on MYO-INOSITOL-1-PHOSPHATE SYNTHASE 3 (SlMIPS3) and induce myo-inositol accumulation in tomato plants under cold stress.”
Claim · model-written summary
SlFHY3 interaction with SlHY5 promoted SlHY5 transcriptional activity on SlMIPS3.
- Taxon
- tomatoSolanum lycopersicume0
- Gene
- SlFHY3e0
- Outcome
- transcriptional activity of SlHY5e0
- Direction
- promotee0
- Qualifier
- under cold stresse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SlFHY3 physically interacts with ELONGATED HYPOCOTYL5 (SlHY5) to promote the transcriptional activity of SlHY5 on MYO-INOSITOL-1-PHOSPHATE SYNTHASE 3 (SlMIPS3) and induce myo-inositol accumulation in tomato plants under cold stress.”
Claim · model-written summary
SlFHY3-SlHY5 interaction induced myo-inositol accumulation under cold stress.
- Taxon
- tomatoSolanum lycopersicume0
- Gene
- SlFHY3e0
- Outcome
- myo-inositol accumulatione0
- Direction
- inducee0
- Qualifier
- under cold stresse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SlFHY3 physically interacts with ELONGATED HYPOCOTYL5 (SlHY5) to promote the transcriptional activity of SlHY5 on MYO-INOSITOL-1-PHOSPHATE SYNTHASE 3 (SlMIPS3) and induce myo-inositol accumulation in tomato plants under cold stress.”
Claim · model-written summary
SlHY5 disruption largely suppressed cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulation.
- Taxon
- tomatoSolanum lycopersicume0
- Material
- SlFHY3-overexpressing plantse0
- Treatment
- Disruption of SlHY5e0
- Outcome
- cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulatione0
- Direction
- suppressese0
- Qualifier
- largelye0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Disruption of SlHY5 and SlMIPS3 largely suppresses the cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulation in tomato.”
Claim · model-written summary
SlMIPS3 disruption largely suppressed cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulation.
- Taxon
- tomatoSolanum lycopersicume0
- Material
- SlFHY3-overexpressing plantse0
- Treatment
- Disruptione0
- Gene
- SlMIPS3e0
- Outcome
- cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulatione0
- Direction
- suppressese0
- Qualifier
- largelye0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Disruption of SlHY5 and SlMIPS3 largely suppresses the cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulation in tomato.”
Claim · model-written summary
SlMIPS3 silencing drastically reduced myo-inositol accumulation.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- silencing of SlMIPS3e0
- Outcome
- myo-inositol accumulatione0
- Direction
- reducese0
- Qualifier
- drasticallye0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“silencing of SlMIPS3 drastically reduces myo-inositol accumulation and compromises LR : FR-induced cold tolerance in tomato.”
Claim · model-written summary
SlMIPS3 silencing compromised LR:FR-induced cold tolerance.
- Taxon
- tomatoSolanum lycopersicume0
- Treatment
- silencing of SlMIPS3e0
- Outcome
- LR : FR-induced cold tolerancee0
- Direction
- compromisese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“silencing of SlMIPS3 drastically reduces myo-inositol accumulation and compromises LR : FR-induced cold tolerance in tomato.”
Claim · model-written summary
SlFHY3 integrates light signals and inositol biosynthesis to control cold tolerance.
- Taxon
- tomatoSolanum lycopersicume0
- Gene
- SlFHY3e0
- Outcome
- cold tolerancee0
- Qualifier
- integrate dynamic environmental light signals and internal cues (inositol biosynthesis)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“our results reveal a crucial role of SlFHY3 in LR : FR-induced cold tolerance in tomato and unravel a novel regulatory mechanism whereby plants integrate dynamic environmental light signals and internal cues (inositol biosynthesis) to induce and control cold tolerance in tomato plants.”
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