Abstract
SAL1, as a negative regulator of stress response signaling, has been studied extensively for its role in plant response to environmental stresses. However, the role of SAL1 in cadmium (Cd) stress response and the underlying mechanism is still unclear. Using an Arabidopsis thaliana loss-of-function mutant of SAL1, we assessed Cd resistance and further explored the Cd toxicity mechanism through analysis of the endoplasmic reticulum (ER) stress response. The loss of SAL1 function greatly improved Cd tolerance and significantly attenuated ER stress in Arabidopsis. Exposure to Cd induced an ER stress response in Arabidopsis as evidenced by unconventional splicing of AtbZIP60 and up-regulation of ER stress-responsive genes. Damage caused by Cd was markedly reduced in the ER stress response double mutant bzip28 bzip60 or by application of the ER stress-alleviating chemical agents, tauroursodeoxycholic acid (TUDCA) and 4-phenyl butyric acid (4-PBA), in wild-type plants. The Cd-induced ER stress in Arabidopsis was also alleviated by loss of function of SAL1. These results identified SAL1 as a new component mediating Cd toxicity and established the role of the ER stress response in Cd toxicity. Additionally, the attenuated ER stress in the sal1 mutant might also shed new light on the mechanism of diverse abiotic stress resistance in the SAL1 loss-of-function mutants.
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Claims 11
Claim · model-written summary
Loss of SAL1 function greatly improved cadmium tolerance in Arabidopsis.
- Taxon
- Arabidopsis
Arabidopsise0 - Treatment
- loss of SAL1 functione0
- Gene
- SAL1e0
- Outcome
- Cd tolerancee0
- Direction
- improvede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The loss of SAL1 function greatly improved Cd tolerance and significantly attenuated ER stress in Arabidopsis.”
Claim · model-written summary
Loss of SAL1 function significantly attenuated cadmium-associated ER stress in Arabidopsis.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- loss of SAL1 functione0
- Gene
- SAL1e0
- Outcome
- ER stresse0
- Direction
- attenuatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The loss of SAL1 function greatly improved Cd tolerance and significantly attenuated ER stress in Arabidopsis.”
Claim · model-written summary
Cadmium exposure induced an ER stress response in Arabidopsis.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- Exposure to Cde0
- Outcome
- ER stress responsee0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Exposure to Cd induced an ER stress response in Arabidopsis as evidenced by unconventional splicing of AtbZIP60 and up-regulation of ER stress-responsive genes.”
Claim · model-written summary
Cadmium exposure induced unconventional splicing of AtbZIP60 in Arabidopsis.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- Exposure to Cde0
- Gene
- AtbZIP60e0
- Outcome
- unconventional splicing of AtbZIP60e0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Exposure to Cd induced an ER stress response in Arabidopsis as evidenced by unconventional splicing of AtbZIP60 and up-regulation of ER stress-responsive genes.”
Claim · model-written summary
Cadmium exposure up-regulated ER stress-responsive genes in Arabidopsis.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- Exposure to Cde0
- Outcome
- ER stress-responsive genese0
- Direction
- up-regulatione0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Exposure to Cd induced an ER stress response in Arabidopsis as evidenced by unconventional splicing of AtbZIP60 and up-regulation of ER stress-responsive genes.”
Claim · model-written summary
Cadmium damage was markedly reduced in the bzip28 bzip60 double mutant.
- Taxon
- ArabidopsisArabidopsist0
- Material
- bzip28 bzip60e0
- Treatment
- ER stress response double mutant bzip28 bzip60e0
- Outcome
- Damage caused by Cde0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Damage caused by Cd was markedly reduced in the ER stress response double mutant bzip28 bzip60”
t0“Arabidopsis”
Claim · model-written summary
TUDCA application markedly reduced cadmium damage in wild-type plants.
- Taxon
- ArabidopsisArabidopsist0
- Material
- wild-type plantse0
- Treatment
- tauroursodeoxycholic acid (TUDCA)e0
- Outcome
- Damage caused by Cde0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Damage caused by Cd was markedly reduced in the ER stress response double mutant bzip28 bzip60 or by application of the ER stress-alleviating chemical agents, tauroursodeoxycholic acid (TUDCA) and 4-phenyl butyric acid (4-PBA), in wild-type plants.”
t0“Arabidopsis”
Claim · model-written summary
4-PBA application markedly reduced cadmium damage in wild-type plants.
- Taxon
- ArabidopsisArabidopsist0
- Material
- wild-type plantse0
- Treatment
- 4-phenyl butyric acid (4-PBA)e0
- Outcome
- Damage caused by Cde0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Damage caused by Cd was markedly reduced in the ER stress response double mutant bzip28 bzip60 or by application of the ER stress-alleviating chemical agents, tauroursodeoxycholic acid (TUDCA) and 4-phenyl butyric acid (4-PBA), in wild-type plants.”
t0“Arabidopsis”
Claim · model-written summary
Loss of SAL1 function alleviated cadmium-induced ER stress in Arabidopsis.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- loss of function of SAL1e0
- Gene
- SAL1e0
- Outcome
- Cd-induced ER stresse0
- Direction
- alleviatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The Cd-induced ER stress in Arabidopsis was also alleviated by loss of function of SAL1.”
Claim · model-written summary
The authors identify SAL1 as a component mediating cadmium toxicity in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- SAL1e0
- Outcome
- Cd toxicitye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“These results identified SAL1 as a new component mediating Cd toxicity”
t0“Arabidopsis”
Claim · model-written summary
The authors infer a role for ER stress response in cadmium toxicity in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Outcome
- Cd toxicitye0
- Qualifier
- ER stress responsee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“established the role of the ER stress response in Cd toxicity.”
t0“Arabidopsis”
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3 papers in the same direction as this paper · 41 in the opposite direction
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See all 45 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.