Abstract
Cross-talk between signal transduction pathways is a central feature of the tightly regulated plant defense signaling network. The potential synergism or antagonism between defense pathways is determined by recognition of the type of pathogen or pathogen-derived elicitor. Our studies have identified WRKY70 as a node of convergence for integrating salicylic acid (SA)- and jasmonic acid (JA)-mediated signaling events during plant response to bacterial pathogens. Here, we challenged transgenic plants altered in WRKY70 expression as well as WRKY70 knockout mutants of Arabidopsis with the fungal pathogens Alternaria brassicicola and Erysiphe cichoracearum to elucidate the role of WRKY70 in modulating the balance between distinct defense responses. Gain or loss of WRKY70 function causes opposite effects on JA-mediated resistance to A. brassicicola and the SA-mediated resistance to E. cichoracearum. While the up-regulation of WRKY70 caused enhanced resistance to E. cichoracearum, it compromised plant resistance to A. brassicicola. Conversely, down-regulation or insertional inactivation of WRKY70 impaired plant resistance to E. cichoracearum. Over-expression of WRKY70 resulted in the suppression of several JA responses including expression of a subset of JA- and A. brassicicola-responsive genes. We show that this WRKY70-controlled suppression of JA-signaling is partly executed by NPR1. The results indicate that WRKY70 has a pivotal role in determining the balance between SA-dependent and JA-dependent defense pathways.
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Claims 6
Claim · model-written summary
WRKY70 integrates salicylic and jasmonic acid signalling during bacterial pathogen response.
- Taxon
- Arabidopsis
Arabidopsise1 - Gene
- WRKY70e0
- Outcome
- integrating salicylic acid (SA)- and jasmonic acid (JA)-mediated signaling eventse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“WRKY70 as a node of convergence for integrating salicylic acid (SA)- and jasmonic acid (JA)-mediated signaling events during plant response to bacterial pathogens.”
e1“mutants of Arabidopsis”
Claim · model-written summary
WRKY70 upregulation enhanced Arabidopsis resistance to E. cichoracearum.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- up-regulation of WRKY70e0
- Interactor
- E. cichoracearum
Golovinomyces cichoracearume0pathogen - Gene
- WRKY70e0
- Outcome
- resistance to E. cichoracearume0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the up-regulation of WRKY70 caused enhanced resistance to E. cichoracearum”
e1“mutants of Arabidopsis”
Claim · model-written summary
WRKY70 upregulation compromised resistance to A. brassicicola.
- Taxon
- ArabidopsisArabidopsise2
- Treatment
- up-regulation of WRKY70e1
- Interactor
- A. brassicicola
Alternaria brassicicolae0pathogen - Gene
- WRKY70e1
- Outcome
- plant resistance to A. brassicicolae0
- Direction
- compromisede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“it compromised plant resistance to A. brassicicola”
e1“up-regulation of WRKY70”
e2“mutants of Arabidopsis”
Claim · model-written summary
WRKY70 downregulation or inactivation impaired resistance to E. cichoracearum.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- down-regulation or insertional inactivation of WRKY70e0
- Interactor
- E. cichoracearumGolovinomyces cichoracearume0pathogen
- Gene
- WRKY70e0
- Outcome
- plant resistance to E. cichoracearume0
- Direction
- impairede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“down-regulation or insertional inactivation of WRKY70 impaired plant resistance to E. cichoracearum.”
e1“mutants of Arabidopsis”
Claim · model-written summary
WRKY70 overexpression suppressed several jasmonic acid responses including defense gene expression.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- Over-expression of WRKY70e0
- Gene
- WRKY70e0
- Outcome
- expression of a subset of JA- and A. brassicicola-responsive genese0
- Direction
- suppressione0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Over-expression of WRKY70 resulted in the suppression of several JA responses including expression of a subset of JA- and A. brassicicola-responsive genes.”
e1“mutants of Arabidopsis”
Claim · model-written summary
NPR1 partly mediates WRKY70 controlled suppression of JA signalling.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- NPR1e0
- Outcome
- suppression of JA-signalinge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“this WRKY70-controlled suppression of JA-signaling is partly executed by NPR1.”
e1“mutants of Arabidopsis”
The same questions in other papers
loss of function · Golovinomyces cichoracearum · ArabidopsisPositive and negative results
3 papers in the same direction as this paper · 3 in the opposite direction
- positive
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