Abstract
In plants, low temperature and dehydration activate a set of genes containing C-repeat/dehydration-responsive elements in their promoter. It has been shown previously that the Arabidopsis CBF/DREB1 transcription activators are critical regulators of gene expression in the signal transduction of cold acclimation. Here, we report the isolation of an apparent homolog of the CBF/DREB1 proteins (CBF4) that plays the equivalent role during drought adaptation. In contrast to the three already identified CBF/DREB1 homologs, which are induced under cold stress, CBF4 gene expression is up-regulated by drought stress, but not by low temperature. Overexpression of CBF4 in transgenic Arabidopsis plants results in the activation of C-repeat/dehydration-responsive element containing downstream genes that are involved in cold acclimation and drought adaptation. As a result, the transgenic plants are more tolerant to freezing and drought stress. Because of the physiological similarity between freezing and drought stress, and the sequence and structural similarity of the CBF/DREB1 and the CBF4 proteins, we propose that the plant's response to cold and drought evolved from a common CBF-like transcription factor, first through gene duplication and then through promoter evolution.
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Claims 5
Claim · model-written summary
CBF4 gene expression is up-regulated by drought stress.
- Taxon
- Arabidopsis
Arabidopsist0 - Treatment
- drought stresse0
- Gene
- CBF4e0
- Outcome
- CBF4 gene expressione0
- Direction
- up-regulatede0
- Comparator
- low temperaturee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Transcription Factor CBF4 Is a Regulator of Drought Adaptation in Arabidopsis”
e0“CBF4 gene expression is up-regulated by drought stress, but not by low temperature”
Claim · model-written summary
CBF4 gene expression is not changed by low temperature.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- low temperaturee0
- Gene
- CBF4e0
- Outcome
- CBF4 gene expressione0
- Direction
- no_changeinferrede0
- Comparator
- drought stresse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Transcription Factor CBF4 Is a Regulator of Drought Adaptation in Arabidopsis”
e0“CBF4 gene expression is up-regulated by drought stress, but not by low temperature”
Claim · model-written summary
Overexpression of CBF4 activates C-repeat/dehydration-responsive element containing downstream genes.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- Overexpression of CBF4e1
- Gene
- CBF4e1
- Outcome
- activation of C-repeat/dehydration-responsive element containing downstream genese1
- Direction
- activatione1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Overexpression of CBF4 in transgenic Arabidopsis plants results in the activation of C-repeat/dehydration-responsive element containing downstream genes that are involved in cold acclimation and drought adaptation”
Claim · model-written summary
Transgenic CBF4 overexpression plants are more tolerant to freezing and drought stress.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- Overexpression of CBF4e1
- Outcome
- freezing and drought stresse2
- Direction
- more tolerant toe2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Transcription Factor CBF4 Is a Regulator of Drought Adaptation in Arabidopsis”
e1“Overexpression of CBF4 in transgenic Arabidopsis plants results in the activation of C-repeat/dehydration-responsive element containing downstream genes that are involved in cold acclimation and drought adaptation”
e2“As a result, the transgenic plants are more tolerant to freezing and drought stress”
Claim · model-written summary
The plant response to cold and drought evolved from a common CBF-like transcription factor through gene duplication and promoter evolution.
Verbatim
e3“the plant's response to cold and drought evolved from a common CBF-like transcription factor”
The same questions in other papers
cold · molecular: expression · ArabidopsisPositive and negative results
20 papers in the same direction as this paper · 18 reporting no difference from an alternative
- positive
- no effect
- positive
35 papers more in this group
See all 39 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.