Abstract
The systemic acquired resistance (SAR) response in Arabidopsis is characterized by the accumulation of salicylic acid (SA), expression of the pathogenesis-related (PR) genes, and enhanced resistance to virulent bacterial and oomycete pathogens. The cpr (constitutive expressor of PR genes) mutants express all three SAR phenotypes. In addition, cpr5 and cpr6 induce expression of PDF1.2, a defense-related gene associated with activation of the jasmonate/ethylene-mediated resistance pathways. cpr5 also forms spontaneous lesions. In contrast, the eds1 (enhanced disease susceptibility) mutation abolishes race-specific resistance conferred by a major subclass of resistance (R) gene products in response to avirulent pathogens. eds1 plants also exhibit increased susceptibility to virulent pathogens. Epistasis experiments were designed to explore the relationship between the cpr- and EDS1-mediated resistance pathways. We found that a null eds1 mutation suppresses the disease resistance phenotypes of both cpr1 and cpr6. In contrast, eds1 only partially suppresses resistance in cpr5, leading us to conclude that cpr5 expresses both EDS1-dependent and EDS1-independent components of plant disease resistance. Although eds1 does not prevent lesion formation on cpr5 leaves, it alters their appearance and reduces their spread. This phenotypic difference is associated with increased pathogen colonization of cpr5 eds1 plants compared to cpr5. The data allow us to place EDS1 as a necessary downstream component of cpr1- and cpr6-mediated responses, but suggest a more complex relationship between EDS1 and cpr5 in plant defense.
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Claims 9
Claim · model-written summary
A null eds1 mutation suppressed the disease resistance phenotypes of cpr1 and cpr6.
- Taxon
- Arabidopsis
Arabidopsise1 - Material
- cpr1 and cpr6e2
- Treatment
- null eds1 mutatione2
- Gene
- eds1e2
- Outcome
- disease resistance phenotypese2
- Direction
- suppressese2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e2“We found that a null eds1 mutation suppresses the disease resistance phenotypes of both cpr1 and cpr6”
Claim · model-written summary
eds1 only partially suppressed resistance in cpr5.
- Taxon
- ArabidopsisArabidopsise1
- Material
- cpr5e3
- Treatment
- eds1e3
- Gene
- eds1e3
- Outcome
- resistancee3
- Direction
- partially suppressese3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e3“eds1 only partially suppresses resistance in cpr5, leading us to conclude that cpr5 expresses both EDS1-dependent and EDS1-independent components of plant disease resistance”
Claim · model-written summary
cpr5 expresses both EDS1-dependent and EDS1-independent components of plant disease resistance.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- EDS1e3
- Outcome
- plant disease resistancee3
- Qualifier
- both EDS1-dependent and EDS1-independent componentse3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e3“eds1 only partially suppresses resistance in cpr5, leading us to conclude that cpr5 expresses both EDS1-dependent and EDS1-independent components of plant disease resistance”
Claim · model-written summary
eds1 does not prevent lesion formation on cpr5 leaves.
- Taxon
- ArabidopsisArabidopsise1
- Material
- cpr5e4
- Treatment
- eds1e4
- Outcome
- lesion formatione4
- Direction
- does not prevente4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e4“Although eds1 does not prevent lesion formation on cpr5 leaves, it alters their appearance and reduces their spread”
Claim · model-written summary
eds1 alters the appearance of cpr5 lesions.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e4“Although eds1 does not prevent lesion formation on cpr5 leaves, it alters their appearance and reduces their spread”
Claim · model-written summary
eds1 reduces the spread of lesions on cpr5 leaves.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e4“Although eds1 does not prevent lesion formation on cpr5 leaves, it alters their appearance and reduces their spread”
Claim · model-written summary
Pathogen colonization is increased in cpr5 eds1 plants compared with cpr5.
- Taxon
- ArabidopsisArabidopsise1
- Material
- cpr5 eds1e5
- Interactor
- pathogene5pathogen
- Outcome
- pathogen colonizatione5
- Direction
- increasede5
- Comparator
- cpr5e5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e5“This phenotypic difference is associated with increased pathogen colonization of cpr5 eds1 plants compared to cpr5”
Claim · model-written summary
EDS1 is a necessary downstream component of cpr1- and cpr6-mediated responses.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- EDS1e6
- Outcome
- cpr1- and cpr6-mediated responsese6
- Qualifier
- necessary downstream componente6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e6“The data allow us to place EDS1 as a necessary downstream component of cpr1- and cpr6-mediated responses, but suggest a more complex relationship between EDS1 and cpr5 in plant defense”
Claim · model-written summary
The relationship between EDS1 and cpr5 in plant defense may be more complex.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- EDS1e6
- Outcome
- plant defensee6
- Qualifier
- more complex relationshipe6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The systemic acquired resistance (SAR) response in Arabidopsis”
e6“The data allow us to place EDS1 as a necessary downstream component of cpr1- and cpr6-mediated responses, but suggest a more complex relationship between EDS1 and cpr5 in plant defense”
The same questions in other papers
loss of function · disease · ArabidopsisPositive and negative results
100 papers in the same direction as this paper · 46 in the opposite direction
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