Abstract
The kinase-associated protein phosphatase (KAPP) is a regulator of the receptor-like kinase (RLK) signaling pathway. Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana. The NaCl hypersensitive phenotype exhibited by rag1 seedlings includes reduced shoot and primary root growth, root tip swelling, and increased lateral root formation. The phenotype exhibited by rag1-1 seedlings is associated with a specific response to Na(+) toxicity. The sensitivity to Na(+) is Ca(2+) independent and is not due to altered intracellular K(+)/Na(+). Analysis of the genetic interaction between rag1-1 and salt overly sensitive1 (sos1-14) revealed that KAPP is not a component of the SOS signal transduction pathway, the only Na(+) homeostasis signaling pathway identified so far in plants. All together, these results implicate KAPP as a functional component of the RLK signaling pathway, which also mediates adaptation to Na(+) stress. RLK pathway components, known to be modulated by NaCl at the messenger RNA level, are constitutively down-regulated in rag1-1 mutant plants. The effect of NaCl on their expression is not altered by the rag1-1 mutation.
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Claims 11
Claim · model-written summary
Loss-of-function rag1-1 and rag1-2 mutations in the KAPP locus cause NaCl hypersensitivity in Arabidopsis thaliana.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae1 - Material
- rag1-1e1
- Treatment
- NaCle1
- Gene
- KAPPe1
- Outcome
- NaCl hypersensitivitye1
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
Claim · model-written summary
Rag1 seedlings under NaCl show reduced shoot and primary root growth.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1e3
- Treatment
- NaCle3
- Outcome
- shoot and primary root growthe3
- Direction
- reducede3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e3“The NaCl hypersensitive phenotype exhibited by rag1 seedlings includes reduced shoot and primary root growth, root tip swelling, and increased lateral root formation”
Claim · model-written summary
Rag1 seedlings under NaCl show root tip swelling.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1e3
- Outcome
- root tip swellinge3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e3“The NaCl hypersensitive phenotype exhibited by rag1 seedlings includes reduced shoot and primary root growth, root tip swelling, and increased lateral root formation”
Claim · model-written summary
Rag1 seedlings under NaCl show increased lateral root formation.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1e3
- Treatment
- NaCle3
- Outcome
- lateral root formatione3
- Direction
- increasede3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e3“The NaCl hypersensitive phenotype exhibited by rag1 seedlings includes reduced shoot and primary root growth, root tip swelling, and increased lateral root formation”
Claim · model-written summary
The rag1-1 phenotype is associated with a specific response to Na(+) toxicity.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1-1e4
- Outcome
- phenotypee4
- Qualifier
- specific response to Na(+) toxicitye4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e4“The phenotype exhibited by rag1-1 seedlings is associated with a specific response to Na(+) toxicity”
Claim · model-written summary
Na(+) sensitivity of rag1 is Ca(2+) independent.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Outcome
- sensitivity to Na(+)e5
- Qualifier
- Ca(2+) independente5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e5“The sensitivity to Na(+) is Ca(2+) independent and is not due to altered intracellular K(+)/Na(+)”
Claim · model-written summary
Na(+) sensitivity is not due to altered intracellular K(+)/Na(+).
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Outcome
- altered intracellular K(+)/Na(+)e5
- Qualifier
- not due toe5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e5“The sensitivity to Na(+) is Ca(2+) independent and is not due to altered intracellular K(+)/Na(+)”
Claim · model-written summary
KAPP is not a component of the SOS Na(+) signal transduction pathway.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1-1e6
- Gene
- KAPPe6
- Outcome
- component of the SOS signal transduction pathwaye6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e6“Analysis of the genetic interaction between rag1-1 and salt overly sensitive1 (sos1-14) revealed that KAPP is not a component of the SOS signal transduction pathway, the only Na(+) homeostasis signaling pathway identified so far in plants”
Claim · model-written summary
KAPP is implicated as a functional component of the RLK signaling pathway that mediates adaptation to Na(+) stress.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Gene
- KAPPe7
- Outcome
- adaptation to Na(+) stresse7
- Qualifier
- RLK signaling pathwaye7
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e7“All together, these results implicate KAPP as a functional component of the RLK signaling pathway, which also mediates adaptation to Na(+) stress”
Claim · model-written summary
RLK pathway components are constitutively down-regulated in rag1-1 mutant plants.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1-1e2
- Outcome
- RLK pathway componentse2
- Direction
- down-regulatede2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e2“RLK pathway components, known to be modulated by NaCl at the messenger RNA level, are constitutively down-regulated in rag1-1 mutant plants”
Claim · model-written summary
The effect of NaCl on RLK pathway component expression is not altered by the rag1-1 mutation.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae1
- Material
- rag1-1e2
- Treatment
- NaCle2
- Outcome
- effect of NaCl on their expressione2
- Direction
- not alterede2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Loss-of-function mutations rag1-1 (root attenuated growth1-1) and rag1-2, in the locus encoding KAPP, cause NaCl hypersensitivity in Arabidopsis thaliana”
e2“The effect of NaCl on their expression is not altered by the rag1-1 mutation”
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