Abstract
Nitric oxide (NO) is a vital immune molecule eliciting resistance to diverse microbial pathogens in humans and animals. However, its functional integration into plant immune networks remains incompletely characterized. In this study, we reveal that both endogenous induction and exogenous supplementation of NO significantly enhance resistance to rice stripe virus (RSV), a Bunyavirus that poses a huge threat to rice production. The nitrate transporter OsNPF6.1 potentiates virus resistance by upregulating the expression of nitrate reductase (OsNR2) and subsequent NO biosynthesis. Functional analyses demonstrate that the disease-specific protein (SP) encoded by RSV interacts with OsNPF6.1 to impair its nitrate transport activity, effectively subverting host immunity to facilitate RSV infection. Notably, this host-pathogen interaction exhibits nitrogen dependency: low nitrate availability attenuates the OsNPF6.1-SP association, preserving transporter functionality and virus resistance. Thus, this study not only provides novel insights into the coordination of growth-defense tradeoffs but also proposes actionable strategies for crop protection via optimized nitrogen management.
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Claims 8
Claim · model-written summary
Endogenous nitric oxide induction enhances rice resistance to rice stripe virus.
- Taxon
- rice
Oryza sativat0 - Treatment
- endogenous inductione0
- Interactor
- rice stripe virus (RSV)e0pathogen
- Outcome
- resistance to rice stripe virus (RSV)e0
- Direction
- enhancee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“both endogenous induction and exogenous supplementation of NO significantly enhance resistance to rice stripe virus (RSV)”
Claim · model-written summary
Exogenous nitric oxide supplementation enhances rice resistance to rice stripe virus.
- Taxon
- riceOryza sativat0
- Treatment
- exogenous supplementation of NOe0
- Interactor
- rice stripe virus (RSV)e0pathogen
- Outcome
- resistance to rice stripe virus (RSV)e0
- Direction
- enhancee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“both endogenous induction and exogenous supplementation of NO significantly enhance resistance to rice stripe virus (RSV)”
Claim · model-written summary
OsNPF6.1 promotes rice virus resistance through OsNR2 expression and nitric oxide biosynthesis.
- Taxon
- riceOryza sativat0
- Gene
- OsNPF6.1e0
- Outcome
- virus resistancee0
- Qualifier
- upregulating the expression of nitrate reductase (OsNR2) and subsequent NO biosynthesise0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“The nitrate transporter OsNPF6.1 potentiates virus resistance by upregulating the expression of nitrate reductase (OsNR2) and subsequent NO biosynthesis.”
Claim · model-written summary
The RSV SP protein interacts with OsNPF6.1 and impairs its nitrate transport activity.
- Taxon
- riceOryza sativat0
- Interactor
- RSVe0pathogen
- Gene
- OsNPF6.1e0
- Outcome
- nitrate transport activitye0
- Direction
- impaire0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“the disease-specific protein (SP) encoded by RSV interacts with OsNPF6.1 to impair its nitrate transport activity”
Claim · model-written summary
SP interaction with OsNPF6.1 facilitates RSV infection by subverting host immunity.
- Taxon
- riceOryza sativat0
- Interactor
- RSVe0pathogen
- Outcome
- RSV infectione0
- Qualifier
- subverting host immunitye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“effectively subverting host immunity to facilitate RSV infection”
Claim · model-written summary
Low nitrate availability attenuates the OsNPF6.1-SP association.
- Taxon
- riceOryza sativat0
- Treatment
- low nitrate availabilitye0
- Interactor
- SPe0pathogen
- Gene
- OsNPF6.1e0
- Outcome
- OsNPF6.1-SP associatione0
- Direction
- attenuatese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“low nitrate availability attenuates the OsNPF6.1-SP association, preserving transporter functionality and virus resistance”
Claim · model-written summary
Under low nitrate availability, transporter functionality and virus resistance are preserved.
- Taxon
- riceOryza sativat0
- Treatment
- low nitrate availabilitye0
- Gene
- OsNPF6.1e0
- Outcome
- transporter functionality and virus resistancee0
- Direction
- preservinge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“low nitrate availability attenuates the OsNPF6.1-SP association, preserving transporter functionality and virus resistance”
Claim · model-written summary
The authors propose optimized nitrogen management for crop protection.
- Taxon
- riceOryza sativat0
- Outcome
- crop protection via optimized nitrogen managemente0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“rice stripe virus (RSV)”
e0“proposes actionable strategies for crop protection via optimized nitrogen management”
The same questions in other papers
nitric oxide · disease · Oryza sativa (rice)Positive and negative results
1 paper in the same direction as this paper · 2 in the opposite direction
- negative
- no effect
- positive
nitrogen · disease · Oryza sativa (rice)Positive and negative results
38 papers in the same direction as this paper · 42 in the opposite direction · 1 reporting no difference from an alternative
- negative
- negative
- negative
78 papers more in this group
See all 82 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.