Abstract
Plant viruses often suppress jasmonic acid (JA)-mediated defences through disturbing JA signalling or biosynthesis pathways to benefit their own infection. Few studies have examined how the precursors of JA biosynthesis are regulated by viral infection. In this study, we demonstrate that rice black-streaked dwarf virus (RBSDV) infection inhibits the production of α-linolenic acid (C18:3), a key JA biosynthesis precursor that is catalysed by a set of fatty acid desaturases (FADs). The viral capsid protein P10 directly interacts with OsFAD7, an ω-3 fatty acid desaturase, and promotes its autophagic degradation through an ATG8-interaction motif (AIM). This disrupts JA production and weakens antiviral defence against RBSDV infection. Genetic analysis reveals that overexpression of OsFAD7 enhances JA levels and resistance to virus. But OsFAD7-mediated antiviral resistance is attenuated if OsCOI1a, a JA receptor, is silenced, indicating that the enhancement of resistance to RBSDV infection conferred by OsFAD7 depends on the JA pathway. Our findings reveal a novel viral strategy that suppresses JA biosynthesis at its metabolic source, providing insights for developing viral protection strategies and virus-resistant crops.
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Claims 8
Claim · model-written summary
RBSDV infection inhibits rice alpha-linolenic acid production.
- Taxon
- rice
Oryza sativae0 - Treatment
- rice black-streaked dwarf virus (RBSDV) infectione0
- Interactor
- rice black-streaked dwarf virusRice black streaked dwarf viruse0pathogen
- Outcome
- production of α-linolenic acid (C18:3)e0
- Direction
- inhibitse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“rice black-streaked dwarf virus (RBSDV) infection inhibits the production of α-linolenic acid (C18:3)”
Claim · model-written summary
Viral P10 directly interacts with OsFAD7.
- Taxon
- riceOryza sativat0
- Gene
- OsFAD7e0
- Outcome
- directly interacts with OsFAD7e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The viral capsid protein P10 directly interacts with OsFAD7”
t0“rice black-streaked dwarf virus (RBSDV) infection”
Claim · model-written summary
Viral P10 promotes autophagic degradation of OsFAD7 through an ATG8-interaction motif.
- Taxon
- riceOryza sativat0
- Gene
- OsFAD7e0
- Outcome
- autophagic degradatione0
- Qualifier
- ATG8-interaction motif (AIM)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The viral capsid protein P10 directly interacts with OsFAD7, an ω-3 fatty acid desaturase, and promotes its autophagic degradation through an ATG8-interaction motif (AIM)”
t0“rice black-streaked dwarf virus (RBSDV) infection”
Claim · model-written summary
This viral process disrupts JA production.
- Taxon
- riceOryza sativat0
- Outcome
- JA productione0
- Direction
- disruptse0
- Qualifier
- Thise0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“This disrupts JA production and weakens antiviral defence against RBSDV infection”
t0“rice black-streaked dwarf virus (RBSDV) infection”
Claim · model-written summary
This viral process weakens rice antiviral defense against RBSDV.
- Taxon
- riceOryza sativat0
- Interactor
- RBSDVRice black streaked dwarf viruse0pathogen
- Outcome
- antiviral defence against RBSDV infectione0
- Direction
- weakense0
- Qualifier
- JA productione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“This disrupts JA production and weakens antiviral defence against RBSDV infection”
t0“rice black-streaked dwarf virus (RBSDV) infection”
Claim · model-written summary
OsFAD7 overexpression increases JA levels.
- Taxon
- riceOryza sativat0
- Treatment
- overexpression of OsFAD7e0
- Gene
- OsFAD7e0
- Outcome
- JA levelse0
- Direction
- enhancese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“overexpression of OsFAD7 enhances JA levels and resistance to virus”
t0“rice black-streaked dwarf virus (RBSDV) infection”
Claim · model-written summary
OsFAD7 overexpression enhances virus resistance.
- Taxon
- riceOryza sativat0
- Treatment
- overexpression of OsFAD7e0
- Interactor
- viruse0pathogen
- Gene
- OsFAD7e0
- Outcome
- resistance to viruse0
- Direction
- enhancese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“overexpression of OsFAD7 enhances JA levels and resistance to virus”
t0“rice black-streaked dwarf virus (RBSDV) infection”
Claim · model-written summary
Silencing OsCOI1a attenuates OsFAD7-mediated antiviral resistance.
- Taxon
- riceOryza sativat0
- Treatment
- OsCOI1a, a JA receptor, is silencede0
- Gene
- OsCOI1ae0
- Outcome
- OsFAD7-mediated antiviral resistancee0
- Direction
- attenuatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“OsFAD7-mediated antiviral resistance is attenuated if OsCOI1a, a JA receptor, is silenced”
t0“rice black-streaked dwarf virus (RBSDV) infection”
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