Abstract
Plant immunity is activated upon pathogen perception and often affects growth and yield when it is constitutively active. How plants fine-tune immune homeostasis in their natural habitats remains elusive. Here, we discover a conserved immune suppression network in cereals that orchestrates immune homeostasis, centering on a Ca 2+ -sensor, RESISTANCE OF RICE TO DISEASES1 (ROD1). ROD1 promotes reactive oxygen species (ROS) scavenging by stimulating catalase activity, and its protein stability is regulated by ubiquitination. ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty. The fungal effector AvrPiz-t structurally mimics ROD1 and activates the same ROS-scavenging cascade to suppress host immunity and promote virulence. We thus reveal a molecular framework adopted by both host and pathogen that integrates Ca 2+ sensing and ROS homeostasis to suppress plant immunity, suggesting a principle for breeding disease-resistant, high-yield crops.
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Claims 8
Claim · model-written summary
ROD1 promotes reactive oxygen species scavenging in rice by stimulating catalase activity.
- Taxon
- rice
Oryza sativat0 - Gene
- ROD1e1
- Outcome
- reactive oxygen species (ROS) scavenginge1
- Qualifier
- by stimulating catalase activitye1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“suppresses rice immunity”
e1“ROD1 promotes reactive oxygen species (ROS) scavenging by stimulating catalase activity, and its protein stability is regulated by ubiquitination”
Claim · model-written summary
ROD1 protein stability in rice is regulated by ubiquitination.
- Taxon
- riceOryza sativat0
- Gene
- ROD1e1
- Outcome
- protein stabilitye1
- Qualifier
- regulated by ubiquitinatione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“suppresses rice immunity”
e1“ROD1 promotes reactive oxygen species (ROS) scavenging by stimulating catalase activity, and its protein stability is regulated by ubiquitination”
Claim · model-written summary
ROD1 disruption increases resistance to multiple pathogens in rice.
- Taxon
- riceOryza sativat0
- Treatment
- ROD1 disruptione2
- Gene
- ROD1e2
- Outcome
- resistance to multiple pathogense2
- Direction
- increaseinferrede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“suppresses rice immunity”
e2“ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty”
Claim · model-written summary
A natural ROD1 allele is prevalent in indica rice with an agroecology-specific distribution.
- Taxon
- indica rice
Oryza sativa Indica Groupe2 - Material
- natural ROD1 allelee2
- Gene
- ROD1e2
- Outcome
- agroecology-specific distributione2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty”
Claim · model-written summary
The natural ROD1 allele enhances resistance in indica rice.
- Taxon
- indica riceOryza sativa Indica Groupe2
- Treatment
- natural ROD1 allelee2
- Gene
- ROD1e2
- Outcome
- resistancee2
- Direction
- enhancese2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty”
Claim · model-written summary
The natural ROD1 allele in indica rice shows no yield penalty.
- Taxon
- indica riceOryza sativa Indica Groupe2
- Treatment
- natural ROD1 allelee2
- Gene
- ROD1e2
- Outcome
- yield penaltye2
- Direction
- no_changeinferrede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty”
Claim · model-written summary
The fungal effector AvrPiz-t structurally mimics ROD1 and suppresses host immunity in rice.
- Taxon
- riceOryza sativat0
- Interactor
- fungal effectore3pathogen
- Gene
- AvrPiz-te3
- Outcome
- host immunitye3
- Qualifier
- structurally mimics ROD1 and activates the same ROS-scavenging cascadee3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“suppresses rice immunity”
e3“The fungal effector AvrPiz-t structurally mimics ROD1 and activates the same ROS-scavenging cascade to suppress host immunity and promote virulence”
Claim · model-written summary
The fungal effector AvrPiz-t promotes virulence in rice through the ROS-scavenging cascade.
- Taxon
- riceOryza sativat0
- Interactor
- fungal effectore3pathogen
- Gene
- AvrPiz-te3
- Outcome
- virulencee3
- Qualifier
- activates the same ROS-scavenging cascadee3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“suppresses rice immunity”
e3“The fungal effector AvrPiz-t structurally mimics ROD1 and activates the same ROS-scavenging cascade to suppress host immunity and promote virulence”
The same questions in other papers
loss of function · disease · Oryza sativa (rice)Positive and negative results
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