Abstract
Late blight caused by Phytophthora infestans seriously threatens world’s potato production. Understanding the responsive mechanism of potato to P. infestans infection and exploring key regulators would be advantageous for improving the late blight resistance. Here, we firstly assessed the late blight resistance of 10 potato cultivars collected from Liangshan Yi Autonomous Prefecture and found that Chuan Liang Shu (CLS) is highly resistant, while Bu Wu Yu (BWY) is extremely susceptible. Comparative transcriptomics further revealed distinct mechanisms of CLS and BWY in response to P. infestans infection, in which CLS activates defense pathways rapidly, while BWY prioritizes energy towards growth and development pathways. Specifically, the up-regulated genes in CLS were largely enriched in oxidation-reduction process and SA-related pathways, resulting in activated ROS-scavenging systems and SA signaling. Clustering analysis for the expression patterns of transcription factors (TFs) demonstrates that the WRKY family members were significantly enriched in a cluster that is specifically induced in CLS after P. infestans infection. Silencing StWRKY26, one of the four WRKYs with higher induction levels, significantly compromise the intrinsic resistance against P. infestans in CLS. Our study enriches the knowledge of transcriptional responses of potato under P. infestans infection and provide candidate genes for breeding potato cultivars with strong late blight resistance. • Comparative transcriptomics reveals CLS (resistant) activates defense pathways quickly, while BWY (susceptible) prioritizes energy for growth. • Elevated SA signaling and oxidation-reduction process contribute to the increased resistance of CLS against P. infestans . • StWRKY26 was identified as a positive regulator for late blight resistance in CLS.
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Claims 9
Claim · model-written summary
Chuan Liang Shu was highly resistant to late blight.
- Taxon
- potato
Solanum tuberosume1 - Material
- Chuan Liang Shue0
- Interactor
- Phytophthora infestans
Phytophthora infestanse2pathogen - Outcome
- highly resistante0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chuan Liang Shu (CLS) is highly resistant”
e1“late blight resistance of 10 potato cultivars”
e2“Phytophthora infestans”
Claim · model-written summary
Bu Wu Yu was extremely susceptible to late blight.
- Taxon
- potatoSolanum tuberosume1
- Material
- Bu Wu Yue0
- Interactor
- Phytophthora infestansPhytophthora infestanse2pathogen
- Outcome
- extremely susceptiblee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Bu Wu Yu (BWY) is extremely susceptible”
e1“late blight resistance of 10 potato cultivars”
e2“Phytophthora infestans”
Claim · model-written summary
The resistant cultivar rapidly activated defense pathways after infection.
- Taxon
- potatoSolanum tuberosume1
- Material
- CLSe0
- Interactor
- P. infestansPhytophthora infestanse2pathogen
- Outcome
- defense pathwayse0
- Direction
- activatese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“CLS activates defense pathways rapidly”
e1“of potato to P. infestans infection”
e2“potato to P. infestans infection”
Claim · model-written summary
The susceptible cultivar prioritized growth and development pathways after infection.
- Taxon
- potatoSolanum tuberosume1
- Material
- BWYe0
- Interactor
- P. infestansPhytophthora infestanse2pathogen
- Outcome
- growth and development pathwayse0
- Direction
- prioritizese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“BWY prioritizes energy towards growth and development pathways”
e1“of potato to P. infestans infection”
e2“potato to P. infestans infection”
Claim · model-written summary
Upregulated genes in the resistant cultivar were enriched in oxidation-reduction processes.
- Taxon
- potatoSolanum tuberosume1
- Material
- CLSe0
- Interactor
- P. infestansPhytophthora infestanse2pathogen
- Outcome
- oxidation-reduction processe0
- Direction
- enrichede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“up-regulated genes in CLS were largely enriched in oxidation-reduction process and SA-related pathways”
e1“of potato to P. infestans infection”
e2“potato to P. infestans infection”
Claim · model-written summary
Upregulated genes in the resistant cultivar were enriched in SA-related pathways.
- Taxon
- potatoSolanum tuberosume1
- Material
- CLSe0
- Interactor
- P. infestansPhytophthora infestanse2pathogen
- Outcome
- SA-related pathwayse0
- Direction
- enrichede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“up-regulated genes in CLS were largely enriched in oxidation-reduction process and SA-related pathways”
e1“of potato to P. infestans infection”
e2“potato to P. infestans infection”
Claim · model-written summary
WRKY transcription factors were significantly enriched in a cluster induced specifically in the resistant cultivar after infection.
- Taxon
- potatoSolanum tuberosume1
- Material
- CLSe0
- Interactor
- P. infestansPhytophthora infestanse0pathogen
- Gene
- WRKY family memberse0
- Outcome
- enriched in a clustere0
- Direction
- enrichede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“WRKY family members were significantly enriched in a cluster that is specifically induced in CLS after P. infestans infection”
e1“of potato to P. infestans infection”
Claim · model-written summary
Silencing StWRKY26 compromised intrinsic resistance in the resistant cultivar.
- Taxon
- potatoSolanum tuberosume1
- Material
- CLSe0
- Treatment
- Silencing StWRKY26e0
- Interactor
- P. infestansPhytophthora infestanse0pathogen
- Gene
- StWRKY26e0
- Outcome
- intrinsic resistance against P. infestanse0
- Direction
- compromisee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Silencing StWRKY26, one of the four WRKYs with higher induction levels, significantly compromise the intrinsic resistance against P. infestans in CLS”
e1“of potato to P. infestans infection”
Claim · model-written summary
The authors identify StWRKY26 as a positive regulator of late-blight resistance.
- Taxon
- potatoSolanum tuberosume1
- Material
- CLSe0
- Interactor
- Phytophthora infestansPhytophthora infestanse2pathogen
- Gene
- StWRKY26e0
- Outcome
- late blight resistancee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“StWRKY26 was identified as a positive regulator for late blight resistance in CLS”
e1“of potato to P. infestans infection”
e2“Phytophthora infestans”
The same questions in other papers
loss of function · Phytophthora infestans · Solanum tuberosum (potato)Positive and negative results
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- negative
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