Abstract
Anti-infection strategies based on suppression of bacterial virulence factors represent a crucial direction for the development of new antibacterial agents to address the resistance triggered by traditional drugs’/pesticides’ bactericidal activity. To identify and obtain more effective and diverse molecules targeting virulence, we prepared a series of 3-hydroxy-2-methyl-1-pyridin-4-(1 H )-one derivatives and evaluated their antibacterial behaviors. Compound B 6 exhibited the highest bioactivity, with half-maximal effective concentration (EC 50 ) values ranging fro9m 10.03 to 30.16 μg mL –1 against three plant pathogenic bacteria. The antibacterial mechanism showed that it could considerably reduce various virulence factors (such as extracellular enzymes, biofilm, and T3SS effectors) and inhibit the expression of virulence factor-related genes. In addition, the control efficiency of compound B 6 against rice bacterial leaf blight at 200 μg mL –1 was 46.15–49.15%, and their control efficiency was improved by approximately 12% after the addition of pesticide additives. Thus, a new class of bactericidal candidates targeting bacterial virulence factors was developed for controlling plant bacterial diseases.
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Claims 5
Claim · model-written summary
Compound B6 had the highest bioactivity among the derivatives, with EC50 values of 10.03 to 30.16 μg mL –1 against three plant pathogenic bacteria.
- Taxon
- rice
Oryza sativae3 - Treatment
- Compound B 6e1
- Interactor
- plant pathogenic bacteriae1pathogen
- Outcome
- half-maximal effective concentration (EC 50 ) valuese1
- Value
- 10.03 to 30.16 μg mL –1e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Compound B 6 exhibited the highest bioactivity, with half-maximal effective concentration (EC 50 ) values ranging fro9m 10.03 to 30.16 μg mL –1 against three plant pathogenic bacteria”
e3“the control efficiency of compound B 6 against rice bacterial leaf blight at 200 μg mL –1 was 46.15–49.15%”
Claim · model-written summary
Compound B6 reduced various bacterial virulence factors, including extracellular enzymes, biofilm and T3SS effectors.
- Taxon
- riceOryza sativae3
- Treatment
- Compound B 6e1
- Interactor
- plant pathogenic bacteriae1pathogen
- Outcome
- various virulence factorse2
- Direction
- reducee2
- Qualifier
- extracellular enzymes, biofilm, and T3SS effectorse2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Compound B 6 exhibited the highest bioactivity, with half-maximal effective concentration (EC 50 ) values ranging fro9m 10.03 to 30.16 μg mL –1 against three plant pathogenic bacteria”
e2“The antibacterial mechanism showed that it could considerably reduce various virulence factors (such as extracellular enzymes, biofilm, and T3SS effectors) and inhibit the expression of virulence factor-related genes”
e3“the control efficiency of compound B 6 against rice bacterial leaf blight at 200 μg mL –1 was 46.15–49.15%”
Claim · model-written summary
Compound B6 inhibited the expression of virulence factor-related genes in plant pathogenic bacteria.
- Taxon
- riceOryza sativae3
- Treatment
- compound B 6e3
- Gene
- virulence factor-related genese2
- Outcome
- expressione2
- Direction
- inhibite2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“The antibacterial mechanism showed that it could considerably reduce various virulence factors (such as extracellular enzymes, biofilm, and T3SS effectors) and inhibit the expression of virulence factor-related genes”
e3“the control efficiency of compound B 6 against rice bacterial leaf blight at 200 μg mL –1 was 46.15–49.15%”
Claim · model-written summary
Compound B6 at 200 μg mL –1 gave a control efficiency of 46.15–49.15% against rice bacterial leaf blight.
- Taxon
- riceOryza sativae3
- Treatment
- compound B 6e3
- Interactor
- bacterial leaf blighte3pathogen
- Outcome
- control efficiencye3
- Direction
- increaseinferrede3
- Value
- 46.15–49.15%e3
- Qualifier
- at 200 μg mL –1e3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“the control efficiency of compound B 6 against rice bacterial leaf blight at 200 μg mL –1 was 46.15–49.15%”
Claim · model-written summary
Adding pesticide additives improved the control efficiency of compound B6 by approximately 12% against rice bacterial leaf blight.
- Taxon
- riceOryza sativae3
- Treatment
- the addition of pesticide additivese4
- Outcome
- control efficiencye4
- Direction
- improvede4
- Value
- approximately 12%e4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“the control efficiency of compound B 6 against rice bacterial leaf blight at 200 μg mL –1 was 46.15–49.15%”
e4“their control efficiency was improved by approximately 12% after the addition of pesticide additives”
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insecticide · control · Oryza sativa (rice)Positive and negative results
11 papers in the same direction as this paper · 4 in the opposite direction
- negative
- no effect
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See all 16 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.