Abstract
Chemical-induced cell death was studied in suspension-cultured tomato (Lycopersicon esculentum Mill.) cells (line MsK8) treated with the anticancer drug camptothecin (CPT) and the heavy metal CdSO4. Within 24 h, ner. Chemical-induced cell death was alleviated by the addition of sub μM concentrations of peptide inhibitors specific to human caspases indicating that cell death proceeds through a mechanism with similarities to animal programmed cell death. Addition of antioxidants greatly reduced chemicalinduced cell death indicating that reactive oxygen species (ROS) are instrumental in cell death. Inhibitors of phospholipase C (PLC) and phospholipase D (PLD) signalling pathway intermediates greatly reduced chemicalinduced cell death. Ethylene, while not inducing cell death when applied alone, stimulated chemical-induced cell death. Application of the ethylene biosynthesis inhibitor aminoethoxy vinylglycine (AVG) reduced chemicalinduced cell death. Together, the results show that toxic chemicals induce programmed cell death exhibiting apoptotic-like features. The cell death process requires increased ROS production and activation of PLC, PLD and ethylene signalling pathways.
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Claims 6
Claim · model-written summary
Caspase inhibitors alleviated chemical-induced tomato cell death.
- Taxon
- tomato
Solanum lycopersicumt0 - Treatment
- peptide inhibitors specific to human caspasese0
- Outcome
- Chemical-induced cell deathe0
- Direction
- alleviatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Chemical-induced cell death was alleviated by the addition of sub μM concentrations of peptide inhibitors specific to human caspases”
Claim · model-written summary
Antioxidants reduced chemically induced tomato cell death.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- antioxidantse0
- Outcome
- chemicalinduced cell deathe0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Addition of antioxidants greatly reduced chemicalinduced cell death”
Claim · model-written summary
Inhibitors of phospholipase C and D signalling reduced chemically induced tomato cell death.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- Inhibitors of phospholipase C (PLC) and phospholipase D (PLD) signalling pathway intermediatese0
- Outcome
- chemicalinduced cell deathe0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Inhibitors of phospholipase C (PLC) and phospholipase D (PLD) signalling pathway intermediates greatly reduced chemicalinduced cell death”
Claim · model-written summary
Ethylene stimulated chemically induced tomato cell death.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- Ethylenee0
- Outcome
- chemical-induced cell deathe0
- Direction
- stimulatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Ethylene, while not inducing cell death when applied alone, stimulated chemical-induced cell death”
Claim · model-written summary
Ethylene alone did not induce tomato cell death.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- Ethylenee0
- Outcome
- cell deathe0
- Direction
- not inducinge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Ethylene, while not inducing cell death when applied alone”
Claim · model-written summary
The ethylene biosynthesis inhibitor AVG reduced chemically induced tomato cell death.
- Taxon
- tomatoSolanum lycopersicumt0
- Treatment
- aminoethoxy vinylglycine (AVG)e0
- Outcome
- chemicalinduced cell deathe0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“tomato”
e0“Application of the ethylene biosynthesis inhibitor aminoethoxy vinylglycine (AVG) reduced chemicalinduced cell death”
The same questions in other papers
ethene · cytology · Solanum lycopersicum (tomato)Positive and negative results
1 paper in the same direction as this paper · 1 in the opposite direction
- positive
- negative
antioxidant · cytology · Solanum lycopersicum (tomato)Results agree
1 paper in the same direction as this paper
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.