Abstract
Aluminum (Al) can target multiple sites of root cells for toxicity, including the cell wall, the plasma membrane and symplastic components. Previous work revealed that the cell cycle checkpoint regulator ATR is required for Al toxicity-induced root growth inhibition in als3 and that the symplastic component DNA is an important target site of Al for the toxicity. However, whether monitoring DNA integrity through ATR-regulated pathway is required for Al-induced root growth inhibition in other Al-sensitive mutants remains unknown. In this study, we demonstrated that the atr mutation could also rescue the Al hypersensitivity and Al-induced cell cycle arrest in star1, which supports the hypothesis that ALS3 and STAR1 function together to be involved in the detoxification of Al in Arabidopsis. However, mutation of ATR could not rescue the Al-sensitive phenotype of almt1 or stop1, both of which are defective in external detoxification mechanisms of Al. We further showed that the Al hypersensitivity and Al-induced quiescent center (QC) differentiation in als1 could also be rescued by the atr mutation. Therefore, our results suggest that ATR-regulated pathway is involved in the modulation of internal Al toxicity-mediated root growth inhibition in Arabidopsis.
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Claims 5
Claim · model-written summary
The atr mutation rescued aluminum hypersensitivity and aluminum-induced cell cycle arrest in star1 Arabidopsis.
- Taxon
- Arabidopsis
Arabidopsist0 - Treatment
- atr mutatione0
- Outcome
- Al hypersensitivity and Al-induced cell cycle arreste0
- Direction
- rescuee0
- Comparator
- star1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the atr mutation could also rescue the Al hypersensitivity and Al-induced cell cycle arrest in star1”
t0“Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis”
Claim · model-written summary
Mutation of ATR could not rescue the Al-sensitive phenotype of almt1 in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Material
- almt1e0
- Treatment
- mutation of ATRe0
- Outcome
- Al-sensitive phenotypee0
- Direction
- could not rescuee0
- Comparator
- almt1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mutation of ATR could not rescue the Al-sensitive phenotype of almt1 or stop1”
t0“Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis”
Claim · model-written summary
Mutation of ATR could not rescue the Al-sensitive phenotype of stop1 in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Material
- stop1e0
- Treatment
- mutation of ATRe0
- Outcome
- Al-sensitive phenotypee0
- Direction
- could not rescuee0
- Comparator
- stop1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mutation of ATR could not rescue the Al-sensitive phenotype of almt1 or stop1”
t0“Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis”
Claim · model-written summary
The atr mutation rescued aluminum hypersensitivity and quiescent center differentiation in als1 Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Material
- als1e0
- Treatment
- atr mutatione0
- Outcome
- Al hypersensitivity and Al-induced quiescent center (QC) differentiatione0
- Direction
- rescuede0
- Comparator
- als1e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the Al hypersensitivity and Al-induced quiescent center (QC) differentiation in als1 could also be rescued by the atr mutation”
t0“Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis”
Claim · model-written summary
The ATR-regulated pathway is involved in the modulation of internal Al toxicity-mediated root growth inhibition in Arabidopsis, according to the authors.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- ATRe0
- Outcome
- root growth inhibitione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“ATR-regulated pathway is involved in the modulation of internal Al toxicity-mediated root growth inhibition in Arabidopsis”
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