Abstract
Immune response during pathogen infection requires extensive transcription reprogramming. A fundamental mechanism of transcriptional regulation is histone acetylation. However, how pathogens interfere with this process to promote disease remains largely unknown. Here we demonstrate that the cytoplasmic effector PsAvh23 produced by the soybean pathogen Phytophthora sojae acts as a modulator of histone acetyltransferase (HAT) in plants. PsAvh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5. As such, PsAvh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility. Expression of PsAvh23 or silencing of GmADA2/GmGCN5 resulted in misregulation of defense-related genes, most likely due to decreased H3K9 acetylation levels at the corresponding loci. This study highlights an effective counter-defense mechanism by which a pathogen effector suppresses the activation of defense genes by interfering with the function of the HAT complex during infection.
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Claims 4
Claim · model-written summary
PsAvh23 binds ADA2 and disrupts its association with GCN5.
- Taxon
- soybean
Glycine maxe1 - Interactor
- Phytophthora sojaePhytophthora sojaee1pathogen
- Gene
- ADA2e0
- Outcome
- disrupts its assemblye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“PsAvh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5”
e1“soybean pathogen Phytophthora sojae”
Claim · model-written summary
PsAvh23 suppresses H3K9 acetylation mediated by ADA2/GCN5.
- Taxon
- soybeanGlycine maxe1
- Interactor
- Phytophthora sojaePhytophthora sojaee1pathogen
- Gene
- ADA2/GCN5e0
- Outcome
- H3K9 acetylatione0
- Direction
- suppressese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“PsAvh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module”
e1“soybean pathogen Phytophthora sojae”
Claim · model-written summary
PsAvh23 increases plant susceptibility.
- Taxon
- soybeanGlycine maxe1
- Treatment
- PsAvh23e0
- Interactor
- Phytophthora sojaePhytophthora sojaee1pathogen
- Outcome
- plant susceptibilitye0
- Direction
- increasese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“PsAvh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility”
e1“soybean pathogen Phytophthora sojae”
Claim · model-written summary
PsAvh23 expression or GmADA2/GmGCN5 silencing misregulated defense genes.
- Taxon
- soybeanGlycine maxe1
- Treatment
- Expression of PsAvh23 or silencing of GmADA2/GmGCN5e0
- Interactor
- Phytophthora sojaePhytophthora sojaee1pathogen
- Gene
- GmADA2/GmGCN5e0
- Outcome
- misregulation of defense-related genese0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Expression of PsAvh23 or silencing of GmADA2/GmGCN5 resulted in misregulation of defense-related genes”
e1“soybean pathogen Phytophthora sojae”
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