Abstract
Phytopathogenic Fusarium species produce the trichothecene family of phytotoxins, which function as a virulence factor during infection of plants. Trichothecenes are classifiable into four major groups by their chemical structures. Recently, the AtNFXL1 gene was reported as a type A trichothecene T-2 toxin-inducible gene. The AtNFXL1 gene encodes a putative transcription factor with similarity to the human transcription repressor NF-X1. The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes. The absence or presence of a carbonyl group at the C8 position distinguishes type A and type B. Growth defect by another type A trichothecene diacetoxyscirpenol (DAS), was weakly enhanced in the atnfxl1 mutant. Diacetoxyscirpenol is distinguishable from T-2 toxin only by the absence of an isovaleryl group at the C8 position. Correspondingly, the AtNFXL1 promoter activity was apparently induced in T-2 toxin-treated and DAS-treated plants. In contrast, DON failed to induce the AtNFXL1 promoter activity. Consequently, the AtNFXL1 gene functions as a signaling component of the type A trichothecene-dependent response in Arabidopsis. In addition, the C8 position of trichothecenes might be closely related to the function of AtNFXL1 gene. Addendum to: Asano T, Masuda D, Yasuda M, Nakashita H, Kudo T, Kimura M, Yamaguchi K, Nishiuchi T. AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response. Plant J 2008; 53:450-64.
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Claims 8
Claim · model-written summary
The atnfxl1 mutant was hypersensitive to T-2 toxin versus wild type.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae0e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
e1“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
Claim · model-written summary
The atnfxl1 mutant was not hypersensitive to DON versus wild type.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
e1“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
Claim · model-written summary
DAS weakly enhanced growth defects in the atnfxl1 mutant.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0e1t0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Growth defect by another type A trichothecene diacetoxyscirpenol (DAS), was weakly enhanced in the atnfxl1 mutant.”
t0“Arabidopsis thaliana grew on agar medium”
e1“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
Claim · model-written summary
T-2 toxin induced AtNFXL1 promoter activity.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0e1t0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Correspondingly, the AtNFXL1 promoter activity was apparently induced in T-2 toxin-treated and DAS-treated plants.”
t0“Arabidopsis thaliana grew on agar medium”
e1“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
Claim · model-written summary
DAS induced AtNFXL1 promoter activity.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0e1t0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Correspondingly, the AtNFXL1 promoter activity was apparently induced in T-2 toxin-treated and DAS-treated plants.”
t0“Arabidopsis thaliana grew on agar medium”
e1“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
Claim · model-written summary
DON did not induce AtNFXL1 promoter activity.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0e1t0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In contrast, DON failed to induce the AtNFXL1 promoter activity.”
t0“Arabidopsis thaliana grew on agar medium”
e1“The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes.”
Claim · model-written summary
AtNFXL1 functions in the type A trichothecene response.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- AtNFXL1e0
- Outcome
- type A trichothecene-dependent responsee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Consequently, the AtNFXL1 gene functions as a signaling component of the type A trichothecene-dependent response in Arabidopsis.”
Claim · model-written summary
The C8 position of trichothecenes may relate to AtNFXL1 function.
- Taxon
- ArabidopsisArabidopsise0t0
- Gene
- AtNFXL1e0
- Outcome
- function of AtNFXL1 genee0
- Qualifier
- might be closely relatede0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In addition, the C8 position of trichothecenes might be closely related to the function of AtNFXL1 gene.”
t0“Arabidopsis thaliana grew on agar medium”
The same questions in other papers
deoxynivalenol · molecular: expression · Arabidopsis thaliana (thale cress)Positive and negative results
2 in the opposite direction
- positive
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.