Abstract
Parthenin, a pseudoguaianolide sesquiterpene lactone and a major component of the ethanol extract of Parthenium hysterophorus was converted to C16-derivative through its pyrazoline derivative to know more about structure-activity relationship. For selected chemical reduction of one of the C=Cs, two reducing reagents i) Na-MeOH, ii) Na2S2O4 were attempted. Na-MeOH treatment of parthenin and its C16-cyclopropyl derivative resulted in addition of two methoxyl groups on C2 and C4. Interestingly, Na2S2O4 chemoselectively reduced only the C=C that is conjugated to lactone moiety. The reagent also did not harm the cyclopropyl ring of C16 derivative of parthenin. It is presumed that both the reductions proceed through free radical mechanism. The stereostructures of these products were ascertained on the basis of 1H NMR, IR and related studies. The transformed products of parthenin were subsequently tested for their biological activity. The bioefficacy of parthenin and its transformed products on germination and early seedling growth of maize and mungbean showed that the chemical modification altered growth regulatory properties. The transformed products, especially at lower concentrations, stimulated root growth and development in both maize and mungbean. However, promotion of shoot growth was seen only in mungbean.
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Claims 4
Claim · model-written summary
Chemical modification of parthenin altered growth regulatory properties in maize and mungbean.
- Taxon
- maize and mungbean
Zea mays.jpg?width=60)
Vigna radiatae0 - Treatment
- chemical modificatione0
- Outcome
- growth regulatory propertiese0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“The bioefficacy of parthenin and its transformed products on germination and early seedling growth of maize and mungbean showed that the chemical modification altered growth regulatory properties.”
Claim · model-written summary
Transformed parthenin products stimulated root growth and development in maize at lower concentrations.
- Treatment
- transformed productse0
- Outcome
- root growth and developmente0
- Direction
- stimulatede0
- Qualifier
- especially at lower concentrationse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The transformed products, especially at lower concentrations, stimulated root growth and development in both maize and mungbean.”
Claim · model-written summary
Transformed parthenin products stimulated root growth and development in mungbean at lower concentrations.
- Taxon
- mungbeanVigna radiatae0
- Treatment
- transformed productse0
- Outcome
- root growth and developmente0
- Direction
- stimulatede0
- Qualifier
- especially at lower concentrationse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The transformed products, especially at lower concentrations, stimulated root growth and development in both maize and mungbean.”
Claim · model-written summary
Shoot growth was promoted only in mungbean.
- Taxon
- mungbeanVigna radiatae0
- Outcome
- shoot growthe0
- Direction
- promotione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“However, promotion of shoot growth was seen only in mungbean.”
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See all 7 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.