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paper W4391946726 ✕

Mechanismobservedoriginal resultnegativesimulated

Claim · model-written summary

Molecular docking indicates that the Cytb-G143S or Cytb-G137R mutations decrease the affinity of Cytb for pyraclostrobin.

Interactor
Fole1pathogen
Gene
Cytb-G143S or Cytb-G137R mutationse1
Compound
pyraclostrobine1
Outcome
affinitye1
Direction
decreasee1

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e1

“The molecular docking results indicate that the Cytb-G143S or Cytb-G137R mutations of Fol lead to a change in the binding mode of Cytb to pyraclostrobin, resulting in a decrease in affinity”

✓ located verbatim in the source · abstract, characters 939–1128

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Observationobservedoriginal resultno effectmeasured

Claim · model-written summary

No cross-resistance was detected between pyraclostrobin and pydiflumetofen, prochloraz or cyazofamid.

Treatment
pyraclostrobine4
Compound
pydiflumetofen, prochloraz, or cyazofamide4
Outcome
cross-resistancee4

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e4

“no cross-resistance was detected between pyraclostrobin and pydiflumetofen, prochloraz, or cyazofamid”

✓ located verbatim in the source · abstract, characters 1534–1635

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Associationobservedoriginal resultnegativemeasured

Claim · model-written summary

Resistance to azoxystrobin, picoxystrobin, fluoxastrobin and pyraclostrobin is positively correlated among resistant mutants.

Material
resistant mutantse3
Compound
azoxystrobin, picoxystrobin, fluoxastrobin, and pyraclostrobine3
Outcome
correlatione3
Direction
positivee3

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e3

“There is a positive correlation observed among azoxystrobin, picoxystrobin, fluoxastrobin, and pyraclostrobin for resistant mutants”

✓ located verbatim in the source · abstract, characters 1392–1523

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Associationobservedoriginal resultpositivemeasured

Claim · model-written summary

Resistant Fol mutants show reduced mycelial growth, virulence and sporulation.

Material
resistant mutantse1
Interactor
Fole0pathogen
Outcome
mycelial growth (25 and 30 °C), virulence, and sporulatione1
Direction
reducede1

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e1

“The resistant mutants exhibit reduced fitness in terms of mycelial growth (25 and 30 °C), virulence, and sporulation”

✓ located verbatim in the source · abstract, characters 1130–1246

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Observationauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

The potential risk of Fol resistance development to pyraclostrobin is low to moderate.

Treatment
pyraclostrobine5
Interactor
Fole5pathogen
Outcome
potential risk of resistance developmente5
Value
low to moderatee5

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e5

“Thus, we conclude that the potential risk of resistance development in Fol toward pyraclostrobin can be categorized as ranging from low to moderate”

✓ located verbatim in the source · abstract, characters 1637–1784

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Mutants carrying the Cytb-G143S mutation suffer a more severe fitness penalty than those carrying the Cytb-G137R mutation.

Treatment
Cytb-G143S mutatione2
Interactor
Fole0pathogen
Outcome
fitness penaltye2
Direction
more severee2
Comparator
those carrying the Cytb-G137R mutatione2

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e2

“Moreover, the mutants carrying the Cytb-G143S mutation suffer a more severe fitness penalty compared to those carrying the Cytb-G137R mutation”

✓ located verbatim in the source · abstract, characters 1248–1390

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Pyraclostrobin showed strong antifungal activity against Fol, with an average EC50 of 0.3739 ± 0.2413 μg/mL over 100 strains.

Treatment
pyraclostrobine1
Interactor
Fole0pathogen
Outcome
average EC 50 valuee1
Value
0.3739 ± 0.2413 μg/mLe1
Qualifier
strong antifungal activitye1

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e1

“The average EC 50 value is 0.3739 ± 0.2413 μg/mL, indicating a strong antifungal activity of pyraclostrobin against Fol”

✓ located verbatim in the source · abstract, characters 534–653

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Observationobservedoriginal resultnegativemeasured

Claim · model-written summary

One Fol mutant showed medium-level resistance to pyraclostrobin due to the Cytb-G137R mutation.

Material
resistant mutantse1
Interactor
Fole0pathogen
Gene
Cytb-G137R mutatione1
Outcome
medium-level resistancee1

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e1

“Furthermore, we generated five resistant mutants through chemical taming and identified four mutants with high-level resistance due to the Cytb-G143S mutation and one mutant with medium-level resistance due to the Cytb-G137R mutation”

✓ located verbatim in the source · abstract, characters 704–937

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)
Observationobservedoriginal resultnegativemeasured

Claim · model-written summary

Four of five chemically tamed Fol mutants showed high-level resistance to pyraclostrobin due to the Cytb-G143S mutation.

Material
resistant mutantse1
Interactor
Fole0pathogen
Gene
Cytb-G143S mutatione1
Outcome
high-level resistancee1

Verbatim

e0

“Tomato wilt disease caused by Fusarium oxysporum f. sp. lycopersici (Fol) results in a decrease in tomato yield and quality”

✓ located verbatim in the source · abstract, characters 0–123
e1

“Furthermore, we generated five resistant mutants through chemical taming and identified four mutants with high-level resistance due to the Cytb-G143S mutation and one mutant with medium-level resistance due to the Cytb-G137R mutation”

✓ located verbatim in the source · abstract, characters 704–937

Title

Resistance Risk and Molecular Mechanism of Tomato Wilt Pathogen Fusarium oxysporum f. sp. lycopersici to Pyraclostrobin

Yushuai Mao; Hui Qiu; Xinlong Gao; et al. Journal of Agricultural and Food Chemistry 2024. doi:10.1021/acs.jafc.3c09907

Other claims from this paper (8)

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