Claim · model-written summary
The ethyl acetate fraction gave hepatocytes with minimum fatty changes, portal vein congestion and mild inflammatory infiltration, comparable to the CCl4 group.
Verbatim
e0“Delonix regia (Hook.) Raf. (Fabaceae) is an ornamental tree with flamboyant flowers”
e4“Ethyl acetate fraction showed significant protection against the elevation in the levels of serum biochemical parameters”
e5“normal hepatocytes with minimum fatty changes, portal vain congestion and mild inflammatory cell infiltration around portal vain comparable to CCl4 group (P< 0.001)”
Title
Pushpendra Singh; Khiromani Nag; Rajesh Garg; et al. Journal of Pharmacognosy and Phytochemistry 2018
Other claims from this paper (10)
- Observation Total phenolic content of the Delonix regia leaf extract was 5.51 g GAE/100 g dried extract.
- Observation Total flavonoid content of the Delonix regia leaf extract was 53.32 g CE/100 g dried extract.
- Observation Thirteen flavonoids and 17 phenolics were identified in the Delonix regia leaf extract.
- Observation Hesperidin had the highest flavonoid content in the Delonix regia leaf extract, at 48622.51 mg/100 g DE.
- Observation Quercetrin followed hesperidin in the Delonix regia leaf extract, at 711.5 mg/100 g DE.
- Observation Hydroxytyrosol was the major identified phenolic in the Delonix regia leaf extract, at 1111.22 mg/100 g DE.
- Observation Catechin followed hydroxytyrosol in the Delonix regia leaf extract, at 1026.11 mg/100 g DE.
- Intervention effect The ethyl acetate fraction of Delonix regia leaves significantly reduced the elevation of serum biochemical parameters in the liver-injury model compared with the CCl4 group.
- Mechanism The hepatoprotective activity of the Delonix regia ethyl acetate fraction may be attributed to its high content of antioxidant phenolic compounds.
- Recommendation The authors suggest that Delonix regia could be used as a natural chemopreventive agent against liver damage.