Abstract
MADS-box transcription factors are a key gene family central to understanding the evolutionary success of land plants. Land plant MADS-box genes are divided into Type I and Type II. They were initially considered orthologous to SRF and MEF2 genes in animals and fungi, respectively, which originated by an ancient duplication before the diversification of extant eukaryotes. However, using updated phylogenetic analyses and AI-based protein structure prediction, we showed that both Type I and Type II genes are plant-specific duplicates derived from MEF2-type ancestors, while ancestral SRF genes were lost before the divergence of the plant lineage. A recent study proposed instead a polyphyletic origin for plant Type I genes. While this study also found that the majority of Type I MADS-box genes in land plants cluster with MEF2 genes, a few genes were grouped as Type I and considered related to SRF genes. By reanalyzing the original data from that study, we do not find supporting evidence for this hypothesis. Moreover, using phylogeny, sequence similarity, and structural evidence, we demonstrate that there is no evidence of SRF-derived genes in land plants.
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Claims 4
Claim · model-written summary
Phylogenetic and structure-prediction analyses show that both Type I and Type II MADS-box genes are plant-specific duplicates derived from MEF2-type ancestors.
- Taxon
- Land PlantsEmbryophytat0
- Gene
- Type I and Type II genese0
- Outcome
- plant-specific duplicates derived from MEF2-type ancestorse0
Verbatim
t0“SRF-type MADS-Box Genes in Land Plants”
e0“both Type I and Type II genes are plant-specific duplicates derived from MEF2-type ancestors”
Claim · model-written summary
Ancestral SRF genes were lost before the divergence of the plant lineage.
- Taxon
- Land PlantsEmbryophytat0
- Gene
- SRF genese0
- Outcome
- ancestral SRF genes were loste0
Verbatim
t0“SRF-type MADS-Box Genes in Land Plants”
e0“ancestral SRF genes were lost before the divergence of the plant lineage”
Claim · model-written summary
Reanalysis of the earlier study data found no support for the hypothesis of a polyphyletic origin of plant Type I genes.
- Taxon
- Land PlantsEmbryophytat0
- Outcome
- supporting evidence for this hypothesise0
- Qualifier
- reanalyzing the original datae0
Verbatim
t0“SRF-type MADS-Box Genes in Land Plants”
e0“By reanalyzing the original data from that study, we do not find supporting evidence for this hypothesis”
Claim · model-written summary
Phylogeny, sequence similarity and structural evidence show no evidence of SRF-derived genes in land plants.
- Taxon
- land plantsEmbryophytae0
- Gene
- SRF-derived genese0
- Outcome
- no evidence of SRF-derived genese0
Verbatim
e0“using phylogeny, sequence similarity, and structural evidence, we demonstrate that there is no evidence of SRF-derived genes in land plants”