Paper · 2026 · Zenodo (CERN European Organization for Nuclear Research)

COMPREHESIVE REVIEW OF VITEX NEGUNDO

Shantha Sheela N.*1, Jothika Kamalakkannan2, Pavithra Muthuraman3, Naveen Nandhakumar4, Madhunisha Jayakumar5, Ganeshram Parthiban6

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verbatim quotes
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Open access · cc-by

Abstract

Vitex negundo Linn., commonly known as Nirgundi or Nochi, is an important medicinal shrub extensively used in Ayurveda, Siddha, Unani, and traditional folk medicines for its wide range of therapeutic applications. The plant is recognized for its strong anti-inflammatory, analgesic, antimicrobial, antioxidant, antiasthmatic, and wound healing properties. Various plant parts including leaves, roots, seeds, flowers, and bark, are traditionally used to treat join pain, swelling, arthritis, asthma, cough, fever, skin infection, digestive disorders, and gynecological problems. The medicinal potential of Vitex negundo is attribute to the presence of diverse phytochemical constituents such as flavonoids (casticin, luteolin), iridoid glycosides (agnuside, negundo side), diterpenoids, lignans, tannins, phenolic acids, and essential oils (B- Caryophyllene, Sabinene, limonene). These bioactive compounds exhibit significant pharmacological effects, supporting its use in controlling inflammation, respiratory ailments, microbial infections, oxidative stress, and hormonal disorders. Pharmacognostical studies reveal the presence of diagnostic characters such as glandular trichomes, diacytic stomata, and a quadrangular stem, which help in plant identification and standardization. Traditional systems describe its therapeutic role in managing Vatha-related condition, especially rheumatism, nerve pain, and Musculo skeletal disorders. Several modern studies have further validated the plant’s medicinal actions through in-vitro and in-vivo research, indicating its potential for developing novel herbal formulation and natural therapeutic agents. Overall, Vitex negundo remains a highly valuable medicinal plant with strong ethnomedicinal relevance and significant scope for future pharmacological and phytochemical investigations.

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Claims 4

Observationobservedreview summarypositivebasis n/a

Claim · model-written summary

Vitex negundo is recognized for strong anti-inflammatory, analgesic, antimicrobial, antioxidant, antiasthmatic and wound healing properties.

Taxon
Vitex negundoVitex negundoe0
Outcome
anti-inflammatory, analgesic, antimicrobial, antioxidant, antiasthmatic, and wound healing propertiese1

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Vitex negundo
Vitex negundo · TaxonDoronenko · CC BY 2.5 · Wikimedia Commons ↗

Verbatim

e0

“Vitex negundo Linn., commonly known as Nirgundi or Nochi, is an important medicinal shrub”

✓ located verbatim in the source · abstract, characters 0–89 · show in text ↑
e1

“The plant is recognized for its strong anti-inflammatory, analgesic, antimicrobial, antioxidant, antiasthmatic, and wound healing properties”

✓ located verbatim in the source · abstract, characters 214–354 · show in text ↑

schema checkedfield values found in the cited quotesPermalinkReport an issue

Observationobservedreview summarybasis n/a

Claim · model-written summary

Vitex negundo contains diverse phytochemical constituents, including flavonoids, iridoid glycosides, diterpenoids, lignans, tannins, phenolic acids and essential oils.

Taxon
Vitex negundoVitex negundoe0
Outcome
presence of diverse phytochemical constituentse2

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Vitex negundo
Vitex negundo · TaxonDoronenko · CC BY 2.5 · Wikimedia Commons ↗

Verbatim

e0

“Vitex negundo Linn., commonly known as Nirgundi or Nochi, is an important medicinal shrub”

✓ located verbatim in the source · abstract, characters 0–89 · show in text ↑
e2

“The medicinal potential of Vitex negundo is attribute to the presence of diverse phytochemical constituents such as flavonoids (casticin, luteolin), iridoid glycosides (agnuside, negundo side), diterpenoids, lignans, tannins, phenolic acids, and essential oils”

✓ located verbatim in the source · abstract, characters 578–838 · show in text ↑
Observationobservedreview summarybasis n/a

Claim · model-written summary

Pharmacognostical studies report diagnostic characters of Vitex negundo, such as glandular trichomes, diacytic stomata and a quadrangular stem, for identification and standardization.

Taxon
Vitex negundoVitex negundoe0
Outcome
diagnostic characterse3

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Vitex negundo
Vitex negundo · TaxonDoronenko · CC BY 2.5 · Wikimedia Commons ↗

Verbatim

e0

“Vitex negundo Linn., commonly known as Nirgundi or Nochi, is an important medicinal shrub”

✓ located verbatim in the source · abstract, characters 0–89 · show in text ↑
e3

“Pharmacognostical studies reveal the presence of diagnostic characters such as glandular trichomes, diacytic stomata, and a quadrangular stem”

✓ located verbatim in the source · abstract, characters 1084–1225 · show in text ↑

schema checkedfield values found in the cited quotesPermalinkReport an issue

Observationobservedreview summarypositivebasis n/a

Claim · model-written summary

Several modern in-vitro and in-vivo studies have validated the medicinal actions of Vitex negundo.

Taxon
Vitex negundoVitex negundoe0
Outcome
medicinal actionse4

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Vitex negundo
Vitex negundo · TaxonDoronenko · CC BY 2.5 · Wikimedia Commons ↗

Verbatim

e0

“Vitex negundo Linn., commonly known as Nirgundi or Nochi, is an important medicinal shrub”

✓ located verbatim in the source · abstract, characters 0–89 · show in text ↑
e4

“Several modern studies have further validated the plant’s medicinal actions through in-vitro and in-vivo research”

✓ located verbatim in the source · abstract, characters 1437–1550 · show in text ↑

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