Abstract
Objective: The purpose of this study was to investigate the phytochemistry and antimicrobial potential of the methanol extracts of the sapwood (EMEHc) and leaves (EMFHc) of Hymenaea courbaril against pathogenic bacteria. Method: For the development, plant products were collected and methanolic extracts of the sapwood and leaves of H. courbaril were prepared, allowing the chemical characterization. In the microbiological tests, the Minimum Inhibitory Concentration (MIC) and the modifying effect of antibiotics against the standard and multidrug-resistant strains of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were determined. Results and Discussion: Chemical characterization revealed the presence of classes of flavonoids, including flavones, flavonols, flanonols, catechins, and xanthones, recognized in both extracts. cEMF and cEHEM demonstrated a synergistic effect in most combinations with antibiotics tested against the bacteria analyzed, suggesting application as a combination therapy. These biological activities were shown to be related to the phytochemical composition identified, since they involve metabolites with proven biological activity.
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Claims 6
Claim · model-written summary
Leaf extract contained flavones, flavonols and flanonols.
- Taxon
- Hymenaea courbaril
Hymenaea courbarile1 - Organ / stage
- leavese1
- Outcome
- flavones, flavonols, flanonolse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chemical characterization revealed the presence of classes of flavonoids, including flavones, flavonols, flanonols, catechins, and xanthones, recognized in both extracts.”
e1“methanol extracts of the sapwood (EMEHc) and leaves (EMFHc) of Hymenaea courbaril”
Claim · model-written summary
Leaf extract contained catechins and xanthones.
- Taxon
- Hymenaea courbarilHymenaea courbarile1
- Organ / stage
- leavese1
- Outcome
- catechins, and xanthonese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chemical characterization revealed the presence of classes of flavonoids, including flavones, flavonols, flanonols, catechins, and xanthones, recognized in both extracts.”
e1“methanol extracts of the sapwood (EMEHc) and leaves (EMFHc) of Hymenaea courbaril”
Claim · model-written summary
Sapwood extract contained flavones, flavonols and flanonols.
- Taxon
- Hymenaea courbarilHymenaea courbarile1
- Organ / stage
- sapwoode1
- Outcome
- flavones, flavonols, flanonolse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chemical characterization revealed the presence of classes of flavonoids, including flavones, flavonols, flanonols, catechins, and xanthones, recognized in both extracts.”
e1“methanol extracts of the sapwood (EMEHc) and leaves (EMFHc) of Hymenaea courbaril”
Claim · model-written summary
Sapwood extract contained catechins and xanthones.
- Taxon
- Hymenaea courbarilHymenaea courbarile1
- Organ / stage
- sapwoode1
- Outcome
- catechins, and xanthonese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chemical characterization revealed the presence of classes of flavonoids, including flavones, flavonols, flanonols, catechins, and xanthones, recognized in both extracts.”
e1“methanol extracts of the sapwood (EMEHc) and leaves (EMFHc) of Hymenaea courbaril”
Claim · model-written summary
cEMF showed synergy in most antibiotic combinations against the analyzed bacteria.
- Taxon
- Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa
Pseudomonas aeruginosa.jpg?width=60)
Escherichia coli
Staphylococcus aureuse1 - Treatment
- cEMFe0
- Outcome
- a synergistic effecte0
- Qualifier
- in most combinations with antibioticse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“cEMF and cEHEM demonstrated a synergistic effect in most combinations with antibiotics tested against the bacteria analyzed, suggesting application as a combination therapy.”
e1“Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa”
Claim · model-written summary
cEHEM showed synergy in most antibiotic combinations against the analyzed bacteria.
- Taxon
- Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosaPseudomonas aeruginosaEscherichia coliStaphylococcus aureuse1
- Treatment
- cEHEMe0
- Outcome
- a synergistic effecte0
- Qualifier
- in most combinations with antibioticse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“cEMF and cEHEM demonstrated a synergistic effect in most combinations with antibiotics tested against the bacteria analyzed, suggesting application as a combination therapy.”
e1“Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa”