Abstract
BACKGROUND: Without controlling weeds, it is estimated that about one third of global crop yields would be lost. Herbicides remain the most effective solution for weed control, but they face multiple challenges, such as the emergence and growth of resistant weed populations. Consequently, there is an urgent need for either herbicides with new modes of action or at least novel chemistries within established modes of action, with outstanding efficacy but without showing cross-resistance to the herbicides present in the prospective markets. RESULTS: Icafolin-methyl is a novel herbicide with a unique biological profile. It is hydrolyzed in planta to the carboxylic acid icafolin. After post-emergence application icafolin-methyl and icafolin both show high efficacy against the most relevant competitive weeds in cold and warm season cropping systems at low application rates, including resistant black-grass and rye-grass biotypes. Biochemical and genetic evidence is provided that icafolin-methyl and icafolin inhibit plant tubulin polymerization probably by binding to ß-tubulins. CONCLUSION: Icafolin-methyl is a novel non-selective herbicide with an established mode of action, but with a superior potency and spectrum, specifically after foliar application. This makes icafolin-methyl fundamentally different from existing tubulin polymerization inhibiting herbicides. It complements the farmers weed control toolbox, particularly with respect to resistance management. © 2024 Society of Chemical Industry.
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Claims 7
Claim · model-written summary
Icafolin-methyl is hydrolyzed in plants to icafolin.
Verbatim
e0“It is hydrolyzed in planta to the carboxylic acid icafolin”
t0“plant‐specific”
Claim · model-written summary
Post-emergence icafolin-methyl was highly effective against competitive weeds at low rates.
- Taxon
- weedse0
- Treatment
- icafolin-methyle0
- Interactor
- black-grass
Alopecurus myosuroidese0weed - Outcome
- efficacy against the most relevant competitive weedse0
- Direction
- highe0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“After post-emergence application icafolin-methyl and icafolin both show high efficacy against the most relevant competitive weeds in cold and warm season cropping systems at low application rates, including resistant black-grass and rye-grass biotypes”
Claim · model-written summary
Post-emergence icafolin was highly effective against competitive weeds at low rates.
- Taxon
- weedse0
- Treatment
- icafoline0
- Outcome
- efficacy against the most relevant competitive weedse0
- Direction
- highe0
LoliumNot reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“After post-emergence application icafolin-methyl and icafolin both show high efficacy against the most relevant competitive weeds in cold and warm season cropping systems at low application rates, including resistant black-grass and rye-grass biotypes”
Claim · model-written summary
Icafolin-methyl inhibits plant tubulin polymerization, probably through binding to beta-tubulins.
Verbatim
e0“Biochemical and genetic evidence is provided that icafolin-methyl and icafolin inhibit plant tubulin polymerization probably by binding to ß-tubulins”
Claim · model-written summary
Icafolin inhibits plant tubulin polymerization, probably through binding to beta-tubulins.
Verbatim
e0“Biochemical and genetic evidence is provided that icafolin-methyl and icafolin inhibit plant tubulin polymerization probably by binding to ß-tubulins”
Claim · model-written summary
Icafolin-methyl has superior potency and spectrum after foliar application.
Verbatim
e0“Icafolin-methyl is a novel non-selective herbicide with an established mode of action, but with a superior potency and spectrum, specifically after foliar application”
t0“plant‐specific”
Claim · model-written summary
The authors consider icafolin-methyl useful for resistance management.
Verbatim
e0“It complements the farmers weed control toolbox, particularly with respect to resistance management”
t0“plant‐specific”