Abstract
Brassinosteroids are steroidal phytohormones that regulate plant development and physiology, including adaptation to environmental stresses. Brassinosteroids are synthesized in the cell interior but bind receptors at the cell surface, necessitating a yet to be identified export mechanism. Here, we show that a member of the ATP-binding cassette (ABC) transporter superfamily, ABCB19, functions as a brassinosteroid exporter. We present its structure in both the substrate-unbound and the brassinosteroid-bound states. Bioactive brassinosteroids are potent activators of ABCB19 ATP hydrolysis activity, and transport assays showed that ABCB19 transports brassinosteroids. In Arabidopsis thaliana , ABCB19 and its close homolog, ABCB1, positively regulate brassinosteroid responses. Our results uncover an elusive export mechanism for bioactive brassinosteroids that is tightly coordinated with brassinosteroid signaling.
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Claims 5
Claim · model-written summary
ABCB19 functions as a brassinosteroid exporter.
- Taxon
- Arabidopsis
Arabidopsist0 - Gene
- ABCB19e0
- Outcome
- functions as a brassinosteroid exportere0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“ABCB19, functions as a brassinosteroid exporter”
t0“Arabidopsis”
Claim · model-written summary
Structures of ABCB19 were presented in substrate unbound and brassinosteroid bound states.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- ABCB19t0
- Outcome
- structure in both the substrate-unbound and the brassinosteroid-bound statese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“We present its structure in both the substrate-unbound and the brassinosteroid-bound states”
t0“Arabidopsis ABC transporter ABCB19”
Claim · model-written summary
Bioactive brassinosteroids potently activate ABCB19 ATP hydrolysis.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- Bioactive brassinosteroidse0
- Gene
- ABCB19e0
- Outcome
- ABCB19 ATP hydrolysis activitye0
- Direction
- potent activatorse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Bioactive brassinosteroids are potent activators of ABCB19 ATP hydrolysis activity”
t0“Arabidopsis”
Claim · model-written summary
Transport assays showed that ABCB19 transports brassinosteroids.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- ABCB19e0
- Outcome
- transports brassinosteroidse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“transport assays showed that ABCB19 transports brassinosteroids”
t0“Arabidopsis”
Claim · model-written summary
ABCB19 and ABCB1 positively regulate brassinosteroid responses in Arabidopsis.
- Taxon
- Arabidopsis thalianaArabidopsis thalianae0
- Gene
- ABCB19 and its close homolog, ABCB1e0
- Outcome
- brassinosteroid responsese0
- Direction
- positively regulatee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis thaliana , ABCB19 and its close homolog, ABCB1, positively regulate brassinosteroid responses”
The same questions in other papers
class · molecular: metabolites · ArabidopsisPositive and negative results
6 papers in the same direction as this paper · 5 in the opposite direction
- positive
- no effect
- no effect
8 papers more in this group
See all 12 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.