Abstract
Rice false smut caused by Ustilaginoidea virens is a devastating rice (Oryza sativa) disease worldwide. However, the molecular mechanisms underlying U. virens-rice interactions are largely unknown. In this study, we identified a secreted protein, Uv1809, as a key virulence factor. Heterologous expression of Uv1809 in rice enhanced susceptibility to rice false smut and bacterial blight. Host-induced gene silencing of Uv1809 in rice enhanced resistance to U. virens, suggesting that Uv1809 inhibits rice immunity and promotes infection by U. virens. Uv1809 suppresses rice immunity by targeting and enhancing rice histone deacetylase OsSRT2-mediated histone deacetylation, thereby reducing H4K5ac and H4K8ac levels and interfering with the transcriptional activation of defence genes. CRISPR-Cas9 edited ossrt2 mutants showed no adverse effects in terms of growth and yield but displayed broad-spectrum resistance to rice pathogens, revealing a potentially valuable genetic resource for breeding disease resistance. Our study provides insight into defence mechanisms against plant pathogens that inactivate plant immunity at the epigenetic level.
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Claims 11
Claim · model-written summary
Uv1809 was identified as a key virulence factor.
- Taxon
- rice
Oryza sativat0 - Gene
- Uv1809e0
- Outcome
- key virulence factore0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“we identified a secreted protein, Uv1809, as a key virulence factor”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
Heterologous Uv1809 expression enhanced rice false smut susceptibility.
- Taxon
- riceOryza sativae0
- Treatment
- Heterologous expression of Uv1809e0
- Interactor
- Ustilaginoidea virens
Ustilaginoidea virenst0pathogen - Gene
- Uv1809e0
- Outcome
- susceptibility to rice false smute0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Heterologous expression of Uv1809 in rice enhanced susceptibility to rice false smut and bacterial blight.”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
Heterologous Uv1809 expression enhanced bacterial blight susceptibility.
- Taxon
- riceOryza sativae0
- Treatment
- Heterologous expression of Uv1809e0
- Gene
- Uv1809e0
- Outcome
- susceptibility to rice false smut and bacterial blighte0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Heterologous expression of Uv1809 in rice enhanced susceptibility to rice false smut and bacterial blight.”
Claim · model-written summary
Host-induced silencing of Uv1809 increased rice resistance to U. virens.
- Taxon
- riceOryza sativae0
- Treatment
- Host-induced gene silencing of Uv1809e0
- Interactor
- U. virensUstilaginoidea virense0pathogen
- Gene
- Uv1809e0
- Outcome
- resistance to U. virense0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Host-induced gene silencing of Uv1809 in rice enhanced resistance to U. virens”
Claim · model-written summary
Uv1809 targets and enhances OsSRT2-mediated histone deacetylation, suppressing rice immunity.
- Taxon
- riceOryza sativae0
- Gene
- OsSRT2e0
- Outcome
- rice immunitye0
- Direction
- suppressese0
- Qualifier
- targeting and enhancing rice histone deacetylase OsSRT2-mediated histone deacetylatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Uv1809 suppresses rice immunity by targeting and enhancing rice histone deacetylase OsSRT2-mediated histone deacetylation”
Claim · model-written summary
The Uv1809–OsSRT2 process reduced H4K5ac and H4K8ac levels.
- Taxon
- riceOryza sativat0
- Gene
- H4K5ac and H4K8ace0
- Outcome
- H4K5ac and H4K8ac levelse0
- Direction
- reducinge0
- Qualifier
- interfering with the transcriptional activation of defence genese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“thereby reducing H4K5ac and H4K8ac levels and interfering with the transcriptional activation of defence genes”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
The Uv1809–OsSRT2 process interfered with defence-gene transcriptional activation.
- Taxon
- riceOryza sativat0
- Outcome
- transcriptional activation of defence genese0
- Direction
- interferinge0
- Qualifier
- reducing H4K5ac and H4K8ac levelse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“thereby reducing H4K5ac and H4K8ac levels and interfering with the transcriptional activation of defence genes”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
Edited ossrt2 mutants showed no adverse growth effect.
- Taxon
- riceOryza sativat0
- Material
- ossrt2 mutantse0
- Treatment
- CRISPR-Cas9 editede0
- Gene
- ossrt2e0
- Outcome
- growthe0
- Direction
- no adverse effectse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“CRISPR-Cas9 edited ossrt2 mutants showed no adverse effects in terms of growth and yield but displayed broad-spectrum resistance to rice pathogens”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
Edited ossrt2 mutants showed no adverse yield effect.
- Taxon
- riceOryza sativat0
- Material
- ossrt2 mutantse0
- Treatment
- CRISPR-Cas9 editede0
- Gene
- ossrt2e0
- Outcome
- yielde0
- Direction
- no adverse effectse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“CRISPR-Cas9 edited ossrt2 mutants showed no adverse effects in terms of growth and yield but displayed broad-spectrum resistance to rice pathogens”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
Edited ossrt2 mutants displayed broad-spectrum resistance to rice pathogens.
- Taxon
- riceOryza sativat0
- Material
- ossrt2 mutantse0
- Treatment
- CRISPR-Cas9 editede0
- Interactor
- rice pathogense0pathogen
- Gene
- ossrt2e0
- Outcome
- broad-spectrum resistance to rice pathogense0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“CRISPR-Cas9 edited ossrt2 mutants showed no adverse effects in terms of growth and yield but displayed broad-spectrum resistance to rice pathogens”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
Claim · model-written summary
The authors identify ossrt2 mutants as a potentially valuable disease-resistance breeding resource.
- Taxon
- riceOryza sativat0
- Outcome
- potentially valuable genetic resource for breeding disease resistancee0
Not reportedComparatorValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“revealing a potentially valuable genetic resource for breeding disease resistance”
t0“Ustilaginoidea virens‐secreted effector Uv1809 suppresses rice immunity”
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See all 8 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.