Abstract
Transcriptional reprogramming is an essential feature of plant immunity and is governed by transcription factors (TFs) and co-regulatory proteins associated with discrete transcriptional complexes. On the other hand, effector proteins from pathogens have been shown to hijack these vast repertoires of plant TFs. Our current knowledge of host genes' role (including TFs) involved in pathogen colonization is based on research employing model plants such as Arabidopsis and rice with minimal efforts in wheat rust interactions. In this study, we begun the research by identifying wheat genes that benefit rust pathogens during infection and editing those genes to provide wheat with passive resistance to rust. We identified the wheat MYC4 transcription factor (TF) located on chromosome 1B ( TaMYC4-1B) as a rust pathogen target. The gene was upregulated only in susceptible lines in the presence of the pathogens. Down-regulation of TaMYC4-1B using barley stripe mosaic virus-induced gene silencing (BSMV-VIGS) in the susceptible cultivar Chinese Spring enhanced its resistance to the stem rust pathogen. Knockout of the TaMYC4-1BL in Cadenza rendered new resistance to races of stem, leaf, and stripe rust pathogens. We developed new germplasm in wheat via modifications of the wheat TaMYC4 − 1BL transcription factor.
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Claims 5
Claim · model-written summary
TaMYC4-1B was identified as a rust pathogen target in wheat.
- Taxon
- wheat
Triticum aestivume4 - Interactor
- rust pathogene4pathogen
- Gene
- TaMYC4-1Be4
- Outcome
- rust pathogen targete4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“identification of a wheat rust pathogen target”
e4“We identified the wheat MYC4 transcription factor (TF) located on chromosome 1B ( TaMYC4-1B) as a rust pathogen target”
Claim · model-written summary
TaMYC4-1B was upregulated only in susceptible wheat lines in the presence of rust pathogens.
- Taxon
- wheatTriticum aestivumt0
- Material
- susceptible linese1
- Interactor
- rust pathogene4pathogen
- Gene
- TaMYC4-1Be4
- Outcome
- upregulatede1
- Direction
- upregulatede1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“identification of a wheat rust pathogen target”
e1“The gene was upregulated only in susceptible lines in the presence of the pathogens”
e4“We identified the wheat MYC4 transcription factor (TF) located on chromosome 1B ( TaMYC4-1B) as a rust pathogen target”
Claim · model-written summary
Down-regulation of TaMYC4-1B by BSMV-VIGS enhanced stem rust resistance of the susceptible wheat cultivar Chinese Spring.
- Taxon
- wheatTriticum aestivumt0
- Material
- Chinese Springe2
- Treatment
- Down-regulation of TaMYC4-1Be2
- Interactor
- stem rust pathogene2pathogen
- Outcome
- resistance to the stem rust pathogene2
- Direction
- enhancede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“identification of a wheat rust pathogen target”
e2“Down-regulation of TaMYC4-1B using barley stripe mosaic virus-induced gene silencing (BSMV-VIGS) in the susceptible cultivar Chinese Spring enhanced its resistance to the stem rust pathogen”
Claim · model-written summary
Knockout of TaMYC4-1BL in Cadenza gave new resistance to races of stem, leaf and stripe rust pathogens.
- Taxon
- wheatTriticum aestivumt0
- Material
- Cadenzae3
- Treatment
- Knockout of the TaMYC4-1BLe3
- Interactor
- stem, leaf, and stripe rust pathogense3pathogen
- Outcome
- new resistance to races of stem, leaf, and stripe rust pathogense3
- Direction
- renderede3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“identification of a wheat rust pathogen target”
e3“Knockout of the TaMYC4-1BL in Cadenza rendered new resistance to races of stem, leaf, and stripe rust pathogens”
Claim · model-written summary
New wheat germplasm was developed by modifying the TaMYC4 transcription factor.
- Taxon
- wheatTriticum aestivume5
- Gene
- TaMYC4e5
- Outcome
- new germplasme5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“identification of a wheat rust pathogen target”
e5“We developed new germplasm in wheat via modifications of the wheat TaMYC4”
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