Abstract
BACKGROUND: Herbicide-resistant weeds pose a challenge to agriculture and food production. New herbicide tolerance traits in crops will provide farmers with more options to effectively manage weeds. Mesotrione, a selective pre- and post-emergent triketone herbicide used in corn production, controls broadleaf and some annual grass weeds via hydroxyphenylpyruvate dioxygenase (HPPD) inhibition. Recently, the rice HIS1 gene, responsible for native tolerance to the selective triketone herbicide benzobicyclon, was identified. Expression of HIS1 also confers a modest level of mesotrione resistance in rice. Here we report the use of the HIS1 gene to develop a mesotrione tolerance trait in soybean. RESULTS: Conventional soybean is highly sensitive to mesotrione. Ectopic expression of a codon-optimized version of the rice HIS1 gene (TDO) in soybean confers a commercial level of mesotrione tolerance. In TDO transgenic soybean plants, mesotrione is rapidly and locally oxidized into noninhibitory metabolites in leaf tissues directly exposed to the herbicide. These metabolites are further converted into compounds similar to known classes of plant secondary metabolites. This rapid metabolism prevents movement of mesotrione from treated leaves into vulnerable emerging leaves. Minimizing the accumulation of the herbicide in vulnerable emerging leaves protects the function of HPPD and carotenoid biosynthesis more generally while providing tolerance to mesotrione. CONCLUSIONS: Mesotrione has a favorable environmental and toxicological profile. The TDO-mediated soybean mesotrione tolerance trait described here provides farmers with a new option to effectively manage difficult-to-control weeds using familiar herbicide chemistry. This trait can also be adapted to other mesotrione-sensitive crops (e.g. cotton) for effective weed management. © 2022 Bayer Crop Science. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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Claims 8
Claim · model-written summary
Conventional soybean is highly sensitive to mesotrione.
- Taxon
- soybean
Glycine maxe0 - Outcome
- highly sensitive to mesotrionee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Conventional soybean is highly sensitive to mesotrione.”
Claim · model-written summary
Ectopic expression of rice HIS1 TDO confers commercial mesotrione tolerance in soybean.
- Taxon
- soybeanGlycine maxe0
- Treatment
- Ectopic expression of a codon-optimized version of the rice HIS1 gene (TDO)e0
- Gene
- rice HIS1e0
- Outcome
- commercial level of mesotrione tolerancee0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Ectopic expression of a codon-optimized version of the rice HIS1 gene (TDO) in soybean confers a commercial level of mesotrione tolerance.”
Claim · model-written summary
Mesotrione is rapidly and locally oxidized to noninhibitory metabolites in directly exposed TDO soybean leaf tissues.
- Taxon
- soybeanGlycine maxe0
- Material
- TDO transgenice0
- Organ / stage
- leaf tissuese0
- Outcome
- mesotrione is rapidly and locally oxidized into noninhibitory metabolitese0
- Qualifier
- directly exposed to the herbicidee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In TDO transgenic soybean plants, mesotrione is rapidly and locally oxidized into noninhibitory metabolites in leaf tissues directly exposed to the herbicide.”
Claim · model-written summary
Mesotrione metabolites are further converted into compounds resembling known plant secondary metabolite classes.
- Taxon
- soybeanGlycine maxt0
- Outcome
- converted into compounds similar to known classes of plant secondary metabolitese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“These metabolites are further converted into compounds similar to known classes of plant secondary metabolites.”
t0“soybean”
Claim · model-written summary
Rapid metabolism prevents mesotrione movement from treated to emerging soybean leaves.
- Taxon
- soybeanGlycine maxt0
- Organ / stage
- vulnerable emerging leavese0
- Outcome
- movement of mesotrionee0
- Direction
- preventse0
- Qualifier
- rapid metabolisme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“This rapid metabolism prevents movement of mesotrione from treated leaves into vulnerable emerging leaves.”
t0“soybean”
Claim · model-written summary
Limiting herbicide accumulation in emerging soybean leaves protects HPPD function and carotenoid biosynthesis and provides tolerance.
- Taxon
- soybeanGlycine maxt0
- Organ / stage
- vulnerable emerging leavese0
- Gene
- HPPDe0
- Outcome
- the function of HPPD and carotenoid biosynthesise0
- Direction
- protectse0
- Qualifier
- Minimizing the accumulation of the herbicidee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Minimizing the accumulation of the herbicide in vulnerable emerging leaves protects the function of HPPD and carotenoid biosynthesis more generally while providing tolerance to mesotrione.”
t0“soybean”
Claim · model-written summary
The authors propose TDO soybean tolerance as an option for controlling difficult weeds with familiar chemistry.
- Taxon
- soybeanGlycine maxe0
- Interactor
- weedse0weed
- Outcome
- effectively manage difficult-to-control weeds using familiar herbicide chemistrye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The TDO-mediated soybean mesotrione tolerance trait described here provides farmers with a new option to effectively manage difficult-to-control weeds using familiar herbicide chemistry.”
Claim · model-written summary
The authors suggest adapting the trait to cotton for weed management.
- Taxon
- cotton
Gossypium hirsutume0 - Outcome
- effective weed managemente0
- Qualifier
- can also be adaptede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“This trait can also be adapted to other mesotrione-sensitive crops (e.g. cotton) for effective weed management.”
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Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.