Abstract
(NbCDPKiso2) from the plasma membrane to the p27-containing intracellular aggregate structures. p27 also induces an intracellular ROS burst in an RBOH-dependent manner. NbCDPKiso2 was shown to be an activator of the p27-triggered ROS accumulations and to be required for RCNMV replication. Importantly, this RBOH-derived ROS is essential for robust viral RNA replication. The need for RBOH-derived ROS was demonstrated for the replication of another (+)RNA virus, brome mosaic virus, suggesting that this characteristic is true for plant (+)RNA viruses. Collectively, our findings revealed a hitherto unknown viral strategy whereby the host ROS-generating machinery is diverted for robust viral RNA replication.
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Claims 5
Claim · model-written summary
NbCDPKiso2 moved from plasma membrane to p27-containing aggregates.
Verbatim
e0“(NbCDPKiso2) from the plasma membrane to the p27-containing intracellular aggregate structures”
t0“plant RNA virus”
Claim · model-written summary
p27 induced an RBOH-dependent intracellular ROS burst.
Verbatim
e0“p27 also induces an intracellular ROS burst in an RBOH-dependent manner”
t0“plant RNA virus”
Claim · model-written summary
NbCDPKiso2 activated p27-triggered ROS accumulation and was required for RCNMV replication.
- Taxon
- plantt0
- Interactor
- RCNMVRed clover necrotic mosaic viruse0pathogen
- Gene
- NbCDPKiso2e0
- Outcome
- p27-triggered ROS accumulationse0
Verbatim
e0“NbCDPKiso2 was shown to be an activator of the p27-triggered ROS accumulations and to be required for RCNMV replication”
t0“plant RNA virus”
Claim · model-written summary
RBOH-derived ROS was essential for robust viral RNA replication.
Verbatim
e0“this RBOH-derived ROS is essential for robust viral RNA replication”
t0“plant RNA virus”
Claim · model-written summary
Brome mosaic virus replication also required RBOH-derived ROS.
- Taxon
- plantt0
- Interactor
- brome mosaic virus
Brome mosaic viruse0pathogen - Gene
- RBOHe0
- Outcome
- replication of another (+)RNA virus, brome mosaic viruse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The need for RBOH-derived ROS was demonstrated for the replication of another (+)RNA virus, brome mosaic virus”
t0“plant RNA virus”