Abstract
Cultured tomatoes are often exposed to a combination of extreme heat and infection with Tomato yellow leaf curl virus (TYLCV). This stress combination leads to intense disease symptoms and yield losses. The response of TYLCV-susceptible and resistant tomatoes to heat stress together with viral infection was compared. The plant heat-stress response was undermined in TYLCV infected plants. The decline correlated with the down-regulation of heat shock transcription factors (HSFs) HSFA2 and HSFB1, and consequently, of HSF-regulated genes Hsp17, Apx1, Apx2 and Hsp90. We proposed that the weakened heat stress response was due to the decreased capacity of HSFA2 to translocate into the nuclei of infected cells. All the six TYLCV proteins were able to interact with tomato HSFA2 in vitro, moreover, coat protein developed complexes with HSFA2 in nuclei. Capturing of HSFA2 by viral proteins could suppress the transcriptional activation of heat stress response genes. Application of both heat and TYLCV stresses was accompanied by the development of intracellular large protein aggregates containing TYLCV proteins and DNA. The maintenance of cellular chaperones in the aggregated state, even after recovery from heat stress, prevents the circulation of free soluble chaperones, causing an additional decrease in stress response efficiency.
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Claims 8
Claim · model-written summary
TYLCV infection undermined the heat-stress response of tomato
- Taxon
- tomato
Solanum lycopersicume7 - Treatment
- TYLCV infected plantse0
- Interactor
- TYLCVTomato yellow leaf curl viruse0pathogen
- Outcome
- heat-stress responsee0
- Direction
- decreaseinferrede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The plant heat-stress response was undermined in TYLCV infected plants”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
Claim · model-written summary
Down-regulation of heat shock transcription factors HSFA2 and HSFB1 correlated with the decline in heat-stress response in tomato
- Taxon
- tomatoSolanum lycopersicume7
- Gene
- HSFA2 and HSFB1e1
- Outcome
- down-regulation of heat shock transcription factorse1
- Direction
- down-regulatione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The decline correlated with the down-regulation of heat shock transcription factors (HSFs) HSFA2 and HSFB1, and consequently, of HSF-regulated genes Hsp17, Apx1, Apx2 and Hsp90”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
Claim · model-written summary
Down-regulation of HSF-regulated genes Hsp17, Apx1, Apx2 and Hsp90 accompanied the decline in heat-stress response in tomato
- Taxon
- tomatoSolanum lycopersicume7
- Gene
- Hsp17, Apx1, Apx2 and Hsp90e1
- Outcome
- HSF-regulated genese1
- Direction
- down-regulatione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“The decline correlated with the down-regulation of heat shock transcription factors (HSFs) HSFA2 and HSFB1, and consequently, of HSF-regulated genes Hsp17, Apx1, Apx2 and Hsp90”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
Claim · model-written summary
Capture of HSFA2 by viral proteins could suppress transcriptional activation of heat stress response genes in tomato
- Taxon
- tomatoSolanum lycopersicume7
- Gene
- HSFA2e2
- Outcome
- transcriptional activation of heat stress response genese2
- Qualifier
- Capturing of HSFA2 by viral proteinse2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“Capturing of HSFA2 by viral proteins could suppress the transcriptional activation of heat stress response genes”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
Claim · model-written summary
All six TYLCV proteins were able to interact with tomato HSFA2 in vitro
- Taxon
- tomatoSolanum lycopersicume3
- Interactor
- TYLCVTomato yellow leaf curl viruse3pathogen
- Gene
- HSFA2e3
- Outcome
- were able to interacte3
- Qualifier
- in vitroe3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“All the six TYLCV proteins were able to interact with tomato HSFA2 in vitro”
Claim · model-written summary
TYLCV coat protein formed complexes with HSFA2 in tomato cell nuclei
- Taxon
- tomatoSolanum lycopersicume7
- Gene
- coat proteine4
- Outcome
- complexes with HSFA2 in nucleie4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e4“coat protein developed complexes with HSFA2 in nuclei”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
Claim · model-written summary
Combined heat and TYLCV stress was accompanied by intracellular large protein aggregates containing TYLCV proteins and DNA in tomato
- Taxon
- tomatoSolanum lycopersicume7
- Treatment
- Application of both heat and TYLCV stressese5
- Interactor
- TYLCVTomato yellow leaf curl viruse5pathogen
- Outcome
- intracellular large protein aggregatese5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e5“Application of both heat and TYLCV stresses was accompanied by the development of intracellular large protein aggregates containing TYLCV proteins and DNA”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
Claim · model-written summary
Maintenance of cellular chaperones in aggregates, even after heat recovery, causes an additional decrease in tomato stress response efficiency
- Taxon
- tomatoSolanum lycopersicume7
- Outcome
- stress response efficiencye6
- Qualifier
- maintenance of cellular chaperones in the aggregated statee6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e6“The maintenance of cellular chaperones in the aggregated state, even after recovery from heat stress, prevents the circulation of free soluble chaperones, causing an additional decrease in stress response efficiency”
e7“Cultured tomatoes are often exposed to a combination of extreme heat”
The same questions in other papers
infection · Tomato yellow leaf curl virus · Solanum lycopersicum (tomato)Positive and negative results
17 papers in the same direction as this paper · 7 in the opposite direction
- positive
- positive
- positive
21 papers more in this group
See all 25 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.