Abstract
BACKGROUND: Besides their nutritional value, vegetables are a source of health-promoting compounds, such as polyphenols, and their content can be influenced by the particular farming method. In this study polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods were chemically characterised and tested in vitro and ex vivo inflammation models. RESULTS: The tested extacts (250-2.5 µg mL(-1) ) were able to reduce both the inflammatory and oxidative stress in LPS-stimulated J774A.1 murine monocyte macrophage cells, by lowering the release of nitric oxide (NO) and reactive oxygen species (ROS) and promoting nuclear translocation of nuclear factor (erythroid-derived 2)-like 2; (Nrf2) and nuclear factor-κB (NF-κB). In this regard, quantitative profiles revealed different amounts of polyphenols, in particular quercetin levels were higher in plants under mineral fertilised treatment. Those extract showed an enhanced anti-inflammatory and antioxidant activity. CONCLUSION: Our data showed the anti-inflammatory and antioxidant potential of Maravilla de Verano polyphenolic extracts. The effect of farming methods on polyphenolic levels was highlighted. The higher reduction of inflammatory mediators release in extracts from plants cultivated under mineral fertilisation treatment was correlated to the higher amount of quercetin. These results can be useful for both nutraceutical or agronomic purposes. © 2016 Society of Chemical Industry.
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Claims 4
Claim · model-written summary
Quercetin levels were higher in lettuce plants under mineral fertilised treatment.
- Taxon
- Lactuca sativa
Lactuca sativae0 - Treatment
- mineral fertilised treatmente1
- Outcome
- quercetin levelse1
- Direction
- highere1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods”
e1“quantitative profiles revealed different amounts of polyphenols, in particular quercetin levels were higher in plants under mineral fertilised treatment”
Claim · model-written summary
Extracts from mineral-fertilised plants showed enhanced anti-inflammatory and antioxidant activity.
- Taxon
- Lactuca sativaLactuca sativae0
- Treatment
- mineral fertilisation treatmente3
- Outcome
- anti-inflammatory and antioxidant activitye2
- Direction
- enhancede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods”
e2“Those extract showed an enhanced anti-inflammatory and antioxidant activity”
e3“The higher reduction of inflammatory mediators release in extracts from plants cultivated under mineral fertilisation treatment was correlated to the higher amount of quercetin”
Claim · model-written summary
Polyphenolic extracts lowered the release of nitric oxide and reactive oxygen species in LPS-stimulated macrophage cells.
- Taxon
- Lactuca sativaLactuca sativae0
- Treatment
- polyphenolic extractse0
- Outcome
- release of nitric oxide (NO) and reactive oxygen species (ROS)e4
- Direction
- loweringe4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods”
e4“by lowering the release of nitric oxide (NO) and reactive oxygen species (ROS)”
Claim · model-written summary
A higher reduction of inflammatory mediator release from extracts of mineral-fertilised plants was correlated with a higher quercetin amount.
- Taxon
- Lactuca sativaLactuca sativae0
- Treatment
- mineral fertilisation treatmente3
- Compound
- quercetine3
- Outcome
- reduction of inflammatory mediators releasee3
- Direction
- highere3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods”
e3“The higher reduction of inflammatory mediators release in extracts from plants cultivated under mineral fertilisation treatment was correlated to the higher amount of quercetin”
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