Abstract
Protein deficiency is the most crucial factor that affects physical growth and development and that increases morbidity and mortality especially in developing countries. Efforts have been made to improve protein quality and quantity in crop plants but with limited success. Here, we report the development of transgenic potatoes with enhanced nutritive value by tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1), in seven genotypic backgrounds suitable for cultivation in different agro-climatic regions. Analyses of the transgenic tubers revealed up to 60% increase in total protein content. In addition, the concentrations of several essential amino acids were increased significantly in transgenic tubers, which are otherwise limited in potato. Moreover, the transgenics also exhibited enhanced photosynthetic activity with a concomitant increase in total biomass. These results are striking because this genetic manipulation also resulted in a moderate increase in tuber yield. The comparative protein profiling suggests that the proteome rebalancing might cause increased protein content in transgenic tubers. Furthermore, the data on field performance and safety evaluation indicate that the transgenic potatoes are suitable for commercial cultivation. In vitro and in vivo studies on experimental animals demonstrate that the transgenic tubers are also safe for human consumption. Altogether, these results emphasize that the expression of AmA1 is a potential strategy for the nutritional improvement of food crops.
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Claims 9
Claim · model-written summary
Transgenic potato tubers had up to 60% more total protein.
- Taxon
- potatoes
Solanum tuberosume1 - Organ / stage
- tuberse0
- Treatment
- tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)e2
- Gene
- AmA1e2
- Outcome
- total protein contente0
- Direction
- increasee0
- Value
- up to 60%e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Analyses of the transgenic tubers revealed up to 60% increase in total protein content.”
e1“development of transgenic potatoes with enhanced nutritive value”
e2“tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)”
Claim · model-written summary
Essential amino acid concentrations increased significantly in transgenic potato tubers.
- Taxon
- potatoesSolanum tuberosume1
- Organ / stage
- tuberse0
- Treatment
- tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)e2
- Gene
- AmA1e2
- Outcome
- concentrations of several essential amino acidse0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the concentrations of several essential amino acids were increased significantly in transgenic tubers”
e1“development of transgenic potatoes with enhanced nutritive value”
e2“tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)”
Claim · model-written summary
Transgenic potatoes had enhanced photosynthetic activity.
- Taxon
- potatoesSolanum tuberosume1
- Treatment
- tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)e2
- Gene
- AmA1e2
- Outcome
- photosynthetic activitye0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the transgenics also exhibited enhanced photosynthetic activity with a concomitant increase in total biomass”
e1“development of transgenic potatoes with enhanced nutritive value”
e2“tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)”
Claim · model-written summary
Transgenic potatoes had increased total biomass.
- Taxon
- potatoesSolanum tuberosume1
- Treatment
- tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)e2
- Gene
- AmA1e2
- Outcome
- total biomasse0
- Direction
- increasee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the transgenics also exhibited enhanced photosynthetic activity with a concomitant increase in total biomass”
e1“development of transgenic potatoes with enhanced nutritive value”
e2“tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)”
Claim · model-written summary
The genetic manipulation moderately increased potato tuber yield.
- Taxon
- potatoesSolanum tuberosume1
- Treatment
- tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)e2
- Gene
- AmA1e2
- Outcome
- tuber yielde0
- Direction
- increasee0
- Qualifier
- moderatee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“this genetic manipulation also resulted in a moderate increase in tuber yield”
e1“development of transgenic potatoes with enhanced nutritive value”
e2“tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1)”
Claim · model-written summary
Comparative protein profiling suggests proteome rebalancing might explain increased tuber protein content.
- Taxon
- potatoesSolanum tuberosume1
- Organ / stage
- tuberse0
- Outcome
- increased protein contente0
- Qualifier
- proteome rebalancinge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The comparative protein profiling suggests that the proteome rebalancing might cause increased protein content in transgenic tubers.”
e1“development of transgenic potatoes with enhanced nutritive value”
Claim · model-written summary
Field performance and safety evaluation indicated transgenic potatoes were suitable for commercial cultivation.
- Taxon
- potatoesSolanum tuberosume0
- Outcome
- suitable for commercial cultivatione0
- Setting
- fielde0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the data on field performance and safety evaluation indicate that the transgenic potatoes are suitable for commercial cultivation”
Claim · model-written summary
Animal studies found transgenic potato tubers safe for human consumption.
- Taxon
- potatoesSolanum tuberosume1
- Organ / stage
- tuberse0
- Outcome
- safe for human consumptione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In vitro and in vivo studies on experimental animals demonstrate that the transgenic tubers are also safe for human consumption.”
e1“development of transgenic potatoes with enhanced nutritive value”
Claim · model-written summary
The authors propose AmA1 expression for nutritional improvement of food crops.
- Taxon
- potatoesSolanum tuberosume1
- Gene
- AmA1e0
- Outcome
- potential strategy for the nutritional improvement of food cropse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the expression of AmA1 is a potential strategy for the nutritional improvement of food crops”
e1“development of transgenic potatoes with enhanced nutritive value”
The same questions in other papers
transgenic · yield · Solanum tuberosum (potato)Positive and negative results
14 papers in the same direction as this paper · 3 in the opposite direction
- no effect
- negative
- negative
14 papers more in this group
See all 18 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.