Abstract
In plants, heat stress responses are controlled by heat stress transcription factors that are conserved among all eukaryotes and can be constitutively expressed or induced by heat. Heat-inducible transcription factors that are distinct from the "classical" heat stress transcription factors have also been reported to contribute to heat tolerance. Here, we show that bZIP28, a gene encoding a putative membrane-tethered transcription factor, is up-regulated in response to heat and that a bZIP28 null mutant has a striking heat-sensitive phenotype. The heat-inducible expression of genes that encode BiP2, an endoplasmic reticulum (ER) chaperone, and HSP26.5-P, a small heat shock protein, is attenuated in the bZIP28 null mutant. An estradiol-inducible bZIP28 transgene induces a variety of heat and ER stress-inducible genes. Moreover, heat stress appears to induce the proteolytic release of the predicted transcription factor domain of bZIP28 from the ER membrane, thereby causing its redistribution to the nucleus. These findings indicate that bZIP28 is an essential component of a membrane-tethered transcription factor-based signaling pathway that contributes to heat tolerance.
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Claims 8
Claim · model-written summary
Heat up-regulated bZIP28.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Treatment
- heate0
- Gene
- bZIP28e0
- Outcome
- bZIP28e0
- Direction
- up-regulatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“bZIP28, a gene encoding a putative membrane-tethered transcription factor, is up-regulated in response to heat”
t0“Arabidopsis thaliana”
Claim · model-written summary
A bZIP28 null mutant had a striking heat-sensitive phenotype.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Material
- bZIP28 null mutante0
- Treatment
- bZIP28 null mutante0
- Outcome
- heat-sensitive phenotypee0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“a bZIP28 null mutant has a striking heat-sensitive phenotype”
t0“Arabidopsis thaliana”
Claim · model-written summary
Heat-inducible BiP2 expression was attenuated in the bZIP28 null mutant.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Material
- bZIP28 null mutante0
- Treatment
- bZIP28 null mutante0
- Gene
- BiP2e0
- Outcome
- heat-inducible expressione0
- Direction
- attenuatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The heat-inducible expression of genes that encode BiP2, an endoplasmic reticulum (ER) chaperone, and HSP26.5-P, a small heat shock protein, is attenuated in the bZIP28 null mutant”
t0“Arabidopsis thaliana”
Claim · model-written summary
Heat-inducible HSP26.5-P expression was attenuated in the bZIP28 null mutant.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Material
- bZIP28 null mutante0
- Treatment
- bZIP28 null mutante0
- Gene
- HSP26.5-Pe0
- Outcome
- heat-inducible expressione0
- Direction
- attenuatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The heat-inducible expression of genes that encode BiP2, an endoplasmic reticulum (ER) chaperone, and HSP26.5-P, a small heat shock protein, is attenuated in the bZIP28 null mutant”
t0“Arabidopsis thaliana”
Claim · model-written summary
Estradiol-inducible bZIP28 induced heat and ER stress-inducible genes.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Treatment
- estradiol-inducible bZIP28 transgenee0
- Gene
- bZIP28e0
- Outcome
- heat and ER stress-inducible genese0
- Direction
- inducese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“An estradiol-inducible bZIP28 transgene induces a variety of heat and ER stress-inducible genes”
t0“Arabidopsis thaliana”
Claim · model-written summary
Heat stress appears to release the bZIP28 transcription factor domain from the ER membrane.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Organ / stage
- ER membranee0
- Treatment
- heat stresse0
- Gene
- bZIP28e0
- Outcome
- proteolytic release of the predicted transcription factor domaine0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“heat stress appears to induce the proteolytic release of the predicted transcription factor domain of bZIP28 from the ER membrane”
t0“Arabidopsis thaliana”
Claim · model-written summary
Heat-induced release apparently redistributed the bZIP28 domain to the nucleus.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- bZIP28e1
- Outcome
- redistribution to the nucleuse0
- Qualifier
- predicted transcription factor domaine1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“thereby causing its redistribution to the nucleus”
e1“predicted transcription factor domain of bZIP28 from the ER membrane”
t0“Arabidopsis thaliana”
Claim · model-written summary
bZIP28 is interpreted as an essential component of a signaling pathway contributing to heat tolerance.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- bZIP28e0
- Outcome
- heat tolerancee0
- Qualifier
- membrane-tethered transcription factor-based signaling pathwaye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“bZIP28 is an essential component of a membrane-tethered transcription factor-based signaling pathway that contributes to heat tolerance”
t0“Arabidopsis thaliana”
The same questions in other papers
transgenic · molecular: expression · Arabidopsis thaliana (thale cress)Positive and negative results
8 papers in the same direction as this paper · 8 in the opposite direction
- no effect
- no effect
- negative
13 papers more in this group
See all 17 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.