Paper · 2006 · Science

A NAC Gene Regulating Senescence Improves Grain Protein, Zinc, and Iron Content in Wheat

Cristobal Uauy; Assaf Distelfeld; Tzion Fahima; et al.

8
claims
9
verbatim quotes
1,598
citations
4
research areas
✓
Open access

Abstract

Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.

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Claims 8

Method / resourceobservedoriginal resultpositivemeasured

Claim · model-written summary

Gpc-B1 was positionally cloned as a wheat QTL associated with increased grain protein, zinc and iron content.

Gene
Gpc-B1e0
Outcome
grain protein, zinc, and iron contente0
Direction
increasede0

Not reportedComparatorValue

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content”

✓ located verbatim in the source · abstract, characters 117–243 · show in text ↑
Mechanismobservedoriginal resultmeasured

Claim · model-written summary

The ancestral wild wheat NAM-B1 allele accelerates senescence.

Material
ancestral wild wheat allelee0
Gene
NAM-B1e0
Outcome
senescencee0
Direction
acceleratese0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains”

✓ located verbatim in the source · abstract, characters 245–419 · show in text ↑
Mechanismobservedoriginal resultpositivemeasured

Claim · model-written summary

The ancestral wild wheat NAM-B1 allele increases nutrient remobilization from leaves to developing grains.

Material
ancestral wild wheat allelee0
Organ / stage
leaves to developing grainse0
Gene
NAM-B1e0
Outcome
nutrient remobilizatione0
Direction
increasese0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains”

✓ located verbatim in the source · abstract, characters 245–419 · show in text ↑
Observationobservedoriginal resultnegativemeasured

Claim · model-written summary

Modern wheat varieties carry a nonfunctional NAM-B1 allele.

Material
modern wheat varietiese0
Gene
NAM-B1e0
Outcome
nonfunctional NAM-B1 allelee0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“modern wheat varieties carry a nonfunctional NAM-B1 allele”

✓ located verbatim in the source · abstract, characters 429–487 · show in text ↑
Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

RNA interference of NAM homologs delayed wheat senescence by more than 3 weeks.

Treatment
RNA interferencee0
Gene
NAM homologse0
Outcome
senescencee0
Direction
delayede0
Value
more than 3 weekse0

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks”

✓ located verbatim in the source · abstract, characters 489–601 · show in text ↑
e1

“wheat grain protein”

✓ located verbatim in the source · abstract, characters 614–633 · show in text ↑
Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

RNA interference of NAM homologs reduced wheat grain protein content by more than 30%.

Treatment
RNA interferencee0
Gene
NAM homologse0
Outcome
grain proteine0
Direction
reducede0
Value
more than 30%e0

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%”

✓ located verbatim in the source · abstract, characters 489–674 · show in text ↑
Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

RNA interference of NAM homologs reduced wheat grain zinc content by more than 30%.

Treatment
RNA interferencee0
Gene
NAM homologse0
Outcome
zince0
Direction
reducede0
Value
more than 30%e0

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%”

✓ located verbatim in the source · abstract, characters 489–674 · show in text ↑
Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

RNA interference of NAM homologs reduced wheat grain iron content by more than 30%.

Treatment
RNA interferencee0
Gene
NAM homologse0
Outcome
iron contente0
Direction
reducede0
Value
more than 30%e0

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Triticum aestivum
Triticum aestivum · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%”

✓ located verbatim in the source · abstract, characters 489–674 · show in text ↑

loss of function · quality: postharvest · Triticum aestivum (wheat)Positive and negative results

8 papers: 1 positive, 7 negative or no effect

6 papers in the same direction as this paper · 1 in the opposite direction

  1. no effect
  2. negative
  3. positive

4 papers more in this group

See all 8 papers →

loss of function · quality: protein · Triticum aestivum (wheat)Positive and negative results

11 papers: 4 positive, 7 negative or no effect

6 papers in the same direction as this paper · 4 in the opposite direction

  1. negative
  2. positive
  3. positive

7 papers more in this group

See all 11 papers →

loss of function · nutrient: content · Triticum aestivum (wheat)Positive and negative results

17 papers: 7 positive, 10 negative or no effect

9 papers in the same direction as this paper · 7 in the opposite direction

  1. positive
  2. positive
  3. positive

13 papers more in this group

See all 17 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.