Paper · 2007 · Journal of Agricultural and Food Chemistry

Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate

Yoshimasa Nakamura; Motoko Yoshimoto; Yoshiyuki Murata; et al.

7
claims
12
verbatim quotes
126
citations
1
research areas
—
Not open access

Abstract

In the present study, papaya (Carica papaya) seed and edible pulp were carefully separated and then the contents of benzyl isothiocyanate and the corresponding glucosinolate (benzyl glucosinolate, glucotropaeolin) quantified in each part. The papaya seed with myrosinase inactivation contained >1 mmol of benzyl glucosinolate in 100 g of fresh seed. This content is equivalent to that of Karami daikon (the hottest Japanese white radish) or that of cress. The papaya seed extract also showed a very high activity of myrosinase and, without myrosinase inactivation, produced 460 micromol of benzyl isothiocyanate in 100 g of seed. In contrast, papaya pulp contained an undetectable amount of benzyl glucosinolate and showed no significant myrosinase activity. The n-hexane extract of the papaya seed homogenate was highly effective in inhibiting superoxide generation and apoptosis induction in HL-60 cells, the activities of which are comparable to those of authentic benzyl isothiocyanate.

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Claims 7

Observationobservedoriginal resultmeasured

Claim · model-written summary

Papaya seed with myrosinase inactivation contained more than 1 mmol of benzyl glucosinolate per 100 g fresh seed.

Taxon
Carica papayaCarica papayae0
Organ / stage
seede1
Outcome
benzyl glucosinolatee1
Value
>1 mmole1
Qualifier
in 100 g of fresh seede1

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e0

“papaya (Carica papaya) seed and edible pulp were carefully separated”

✓ located verbatim in the source · abstract, characters 22–90 · show in text ↑
e1

“The papaya seed with myrosinase inactivation contained >1 mmol of benzyl glucosinolate in 100 g of fresh seed”

✓ located verbatim in the source · abstract, characters 239–348 · show in text ↑
Observationobservedoriginal resultno effectmeasured

Claim · model-written summary

The benzyl glucosinolate content of papaya seed is equivalent to that of Karami daikon.

Taxon
Carica papayaCarica papayae0
Compound
benzyl glucosinolatee1
Outcome
contente2
Direction
equivalente2
Qualifier
or that of cresse2
Comparator
Karami daikone2

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e0

“papaya (Carica papaya) seed and edible pulp were carefully separated”

✓ located verbatim in the source · abstract, characters 22–90 · show in text ↑
e1

“The papaya seed with myrosinase inactivation contained >1 mmol of benzyl glucosinolate in 100 g of fresh seed”

✓ located verbatim in the source · abstract, characters 239–348 · show in text ↑
e2

“This content is equivalent to that of Karami daikon (the hottest Japanese white radish) or that of cress”

✓ located verbatim in the source · abstract, characters 350–454 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Papaya seed extract showed very high myrosinase activity.

Taxon
Carica papayaCarica papayae0
Outcome
activity of myrosinasee3
Qualifier
very highe3

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e0

“papaya (Carica papaya) seed and edible pulp were carefully separated”

✓ located verbatim in the source · abstract, characters 22–90 · show in text ↑
e3

“The papaya seed extract also showed a very high activity of myrosinase and, without myrosinase inactivation, produced 460 micromol of benzyl isothiocyanate in 100 g of seed”

✓ located verbatim in the source · abstract, characters 456–628 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Papaya seed extract without myrosinase inactivation produced 460 micromol of benzyl isothiocyanate per 100 g of seed.

Taxon
Carica papayaCarica papayae0
Outcome
benzyl isothiocyanatee3
Value
460 micromole3
Qualifier
in 100 g of seede3

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e0

“papaya (Carica papaya) seed and edible pulp were carefully separated”

✓ located verbatim in the source · abstract, characters 22–90 · show in text ↑
e3

“The papaya seed extract also showed a very high activity of myrosinase and, without myrosinase inactivation, produced 460 micromol of benzyl isothiocyanate in 100 g of seed”

✓ located verbatim in the source · abstract, characters 456–628 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Papaya pulp contained an undetectable amount of benzyl glucosinolate.

Taxon
papayaCarica papayae4
Organ / stage
pulpe4
Outcome
benzyl glucosinolatee4
Value
undetectable amounte4

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e4

“In contrast, papaya pulp contained an undetectable amount of benzyl glucosinolate and showed no significant myrosinase activity”

✓ located verbatim in the source · abstract, characters 630–757 · show in text ↑
Observationobservedoriginal resultno effectnot significant (as stated)measured

Claim · model-written summary

Papaya pulp showed no significant myrosinase activity.

Taxon
papayaCarica papayae4
Organ / stage
pulpe4
Outcome
myrosinase activitye4
Qualifier
no significante4

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e4

“In contrast, papaya pulp contained an undetectable amount of benzyl glucosinolate and showed no significant myrosinase activity”

✓ located verbatim in the source · abstract, characters 630–757 · show in text ↑
Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

The n-hexane extract of papaya seed inhibited superoxide generation and apoptosis induction in HL-60 cells, comparable to authentic benzyl isothiocyanate.

Taxon
papayaCarica papayae5
Treatment
n-hexane extract of the papaya seed homogenatee5
Outcome
superoxide generation and apoptosis inductione5
Direction
inhibitinge5
Qualifier
in HL-60 cellse5
Comparator
authentic benzyl isothiocyanatee5

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Carica papaya
Carica papaya · TaxonCarlquist, Sherwin John, 1930-2021 · CC BY 4.0 · Wikimedia Commons ↗

Verbatim

e5

“The n-hexane extract of the papaya seed homogenate was highly effective in inhibiting superoxide generation and apoptosis induction in HL-60 cells, the activities of which are comparable to those of authentic benzyl isothiocyanate”

✓ located verbatim in the source · abstract, characters 759–989 · show in text ↑

botanical · physiology: oxidative · Carica papaya (papaya)Positive and negative results

2 papers: 1 positive, 1 negative or no effect

1 in the opposite direction

  1. negative
See all 2 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.