Abstract
JP-8 is the battlefield fuel for DoD and NATO countries. Questions have been raised about the human health implications of occupational exposure to JP-8, as compared to the phased out JP-4. No scientific information is available on the effect of repeated skin contact with JP-8. Before initiating an investigation using the rat as an animal model for skin irritation with jet fuels, several laboratory procedures needed to be addressed. During this preliminary dose range finding study, an opportunity to preview the nature and severity of skin lesions to be encountered in a subchronic repeated dose jet fuel study was gained. Depending on the type of fuel and the frequency of application, a range of skin response scores was determined, primarily on the basis of histopathological evaluation. In general, JP-4 was less irritating than JP-8. Seven recommendations for a definitive study are given.
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Claims 0
Judged off_topic: no plant question — claims were not extracted. This is a scope decision by the model, not a statement about the paper’s findings.